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{{STRUCTURE_3n57|  PDB=3n57  |  SCENE=  }}
===Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)===
{{ABSTRACT_PUBMED_021098034}}


==Disease==
==Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)==
[[http://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN]] Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6) [MIM:[http://omim.org/entry/612201 612201]]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.<ref>PMID:18614783</ref>  
<StructureSection load='3n57' size='340' side='right'caption='[[3n57]], [[Resolution|resolution]] 3.03&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[3n57]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N57 FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref><ref>PMID:17613531</ref><ref>PMID:18986166</ref> [[http://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN]] Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.<ref>PMID:1672777</ref>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.03&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n57 OCA], [https://pdbe.org/3n57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n57 RCSB], [https://www.ebi.ac.uk/pdbsum/3n57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n57 ProSAT]</span></td></tr>
[[3n57]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N57 OCA].
</table>
== Function ==
[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>  


==See Also==
==See Also==
*[[Insulin-Degrading Enzyme|Insulin-Degrading Enzyme]]
*[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:021098034</ref><references group="xtra"/><references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Insulysin]]
[[Category: Large Structures]]
[[Category: Funke, T.]]
[[Category: Funke T]]
[[Category: Guo, Q.]]
[[Category: Guo Q]]
[[Category: Tang, W J.]]
[[Category: Tang W-J]]
[[Category: A-beta degrading enzyme]]
[[Category: Cardiac]]
[[Category: Cardiovascular regulation]]
[[Category: Cryptidase]]
[[Category: Diabetes mellitus]]
[[Category: Disease mutation]]
[[Category: Disulfide bond]]
[[Category: Hormone]]
[[Category: Human insulin-degradng enzyme]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hormone complex]]
[[Category: Insulin]]
[[Category: Insulinase]]
[[Category: Insulysin]]
[[Category: Metal-binding]]
[[Category: Metalloprotease]]
[[Category: Natriuretic factor]]
[[Category: Natriuretic peptide]]
[[Category: Protease]]
[[Category: Secreted]]

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