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{{STRUCTURE_1bl8|  PDB=1bl8  |  SCENE=  }}
===POTASSIUM CHANNEL (KCSA) FROM STREPTOMYCES LIVIDANS===
{{ABSTRACT_PUBMED_9525859}}


==About this Structure==
==POTASSIUM CHANNEL (KCSA) FROM STREPTOMYCES LIVIDANS==
[[1bl8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. The February 2003 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Potassium Channels''  by Shuchismita Dutta and David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2003_2 10.2210/rcsb_pdb/mom_2003_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL8 OCA].  
<StructureSection load='1bl8' size='340' side='right'caption='[[1bl8]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1bl8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. The February 2003 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Potassium Channels''  by Shuchismita Dutta and David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2003_2 10.2210/rcsb_pdb/mom_2003_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BL8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bl8 OCA], [https://pdbe.org/1bl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bl8 RCSB], [https://www.ebi.ac.uk/pdbsum/1bl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bl8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bl/1bl8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bl8 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Amino Acids|Amino Acids]]
*[[Cation-pi interactions|Cation-pi interactions]]
*[[Cation-pi interactions|Cation-pi interactions]]
*[[Glutamate receptor (GluA2)|Glutamate receptor (GluA2)]]
*[[Glutamate receptor (GluA2)|Glutamate receptor (GluA2)]]
*[[Nobel Prizes for 3D Molecular Structure|Nobel Prizes for 3D Molecular Structure]]
*[[Ionotropic receptors|Ionotropic receptors]]
*[[Potassium Channel|Potassium Channel]]
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
*[[User:Eric Martz/Introduction to Structural Bioinformatics I|User:Eric Martz/Introduction to Structural Bioinformatics I]]
== References ==
*[[User:Eric Martz/Introduction to Structural Bioinformatics I%2C 2013|User:Eric Martz/Introduction to Structural Bioinformatics I%2C 2013]]
<references/>
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:009525859</ref><ref group="xtra">PMID:011836517</ref><ref group="xtra">PMID:011836519</ref><ref group="xtra">PMID:015565171</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Potassium Channels]]
[[Category: Potassium Channels]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Streptomyces lividans]]
[[Category: Streptomyces lividans]]
[[Category: Cabral, J M.]]
[[Category: Cabral JM]]
[[Category: Chait, B T.]]
[[Category: Chait BT]]
[[Category: Cohen, S L.]]
[[Category: Cohen SL]]
[[Category: Doyle, D A.]]
[[Category: Doyle DA]]
[[Category: Gulbis, J M.]]
[[Category: Gulbis JM]]
[[Category: Kuo, A.]]
[[Category: Kuo A]]
[[Category: Mackinnon, R.]]
[[Category: Mackinnon R]]
[[Category: Pfuetzner, R A.]]
[[Category: Pfuetzner RA]]
[[Category: Integral membrane protein]]
[[Category: Membrane protein]]
[[Category: Potassium channel]]

Latest revision as of 09:37, 7 February 2024

POTASSIUM CHANNEL (KCSA) FROM STREPTOMYCES LIVIDANSPOTASSIUM CHANNEL (KCSA) FROM STREPTOMYCES LIVIDANS

Structural highlights

1bl8 is a 4 chain structure with sequence from Streptomyces lividans. The February 2003 RCSB PDB Molecule of the Month feature on Potassium Channels by Shuchismita Dutta and David S. Goodsell is 10.2210/rcsb_pdb/mom_2003_2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KCSA_STRLI Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Schrempf H, Schmidt O, Kummerlen R, Hinnah S, Muller D, Betzler M, Steinkamp T, Wagner R. A prokaryotic potassium ion channel with two predicted transmembrane segments from Streptomyces lividans. EMBO J. 1995 Nov 1;14(21):5170-8. PMID:7489706

1bl8, resolution 3.20Å

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