1k0m: Difference between revisions
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== | ==Crystal structure of a soluble monomeric form of CLIC1 at 1.4 angstroms== | ||
[[1k0m]] is a 2 chain structure with sequence from [ | <StructureSection load='1k0m' size='340' side='right'caption='[[1k0m]], [[Resolution|resolution]] 1.40Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1k0m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K0M FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k0m OCA], [https://pdbe.org/1k0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k0m RCSB], [https://www.ebi.ac.uk/pdbsum/1k0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k0m ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CLIC1_HUMAN CLIC1_HUMAN] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.<ref>PMID:9139710</ref> <ref>PMID:10834939</ref> <ref>PMID:11195932</ref> <ref>PMID:11940526</ref> <ref>PMID:11978800</ref> <ref>PMID:11551966</ref> <ref>PMID:14613939</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k0/1k0m_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k0m ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[ | *[[Ion channels 3D structures|Ion channels 3D structures]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bauskin | [[Category: Large Structures]] | ||
[[Category: Breit | [[Category: Bauskin AR]] | ||
[[Category: Campbell | [[Category: Breit SN]] | ||
[[Category: Curmi | [[Category: Campbell TJ]] | ||
[[Category: DeMaere | [[Category: Curmi PMG]] | ||
[[Category: Fairlie | [[Category: DeMaere MZ]] | ||
[[Category: Harrop | [[Category: Fairlie WD]] | ||
[[Category: Jankova | [[Category: Harrop SJ]] | ||
[[Category: Mazzanti | [[Category: Jankova L]] | ||
[[Category: Pankhurst | [[Category: Mazzanti M]] | ||
[[Category: Qiu | [[Category: Pankhurst S]] | ||
[[Category: Reztsova | [[Category: Qiu MR]] | ||
[[Category: Tonini | [[Category: Reztsova T]] | ||
[[Category: Valenzuela | [[Category: Tonini R]] | ||
[[Category: Warton | [[Category: Valenzuela SM]] | ||
[[Category: Wu | [[Category: Warton K]] | ||
[[Category: Wu WM]] | |||