2b60: Difference between revisions

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[[Image:2b60.gif|left|200px]]<br /><applet load="2b60" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2b60, resolution 2.200&Aring;" />
'''Structure of HIV-1 protease mutant bound to Ritonavir'''<br />


==About this Structure==
==Structure of HIV-1 protease mutant bound to Ritonavir==
2B60 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=RIT:'>RIT</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B60 OCA].  
<StructureSection load='2b60' size='340' side='right'caption='[[2b60]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2b60]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B60 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=RIT:RITONAVIR'>RIT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b60 OCA], [https://pdbe.org/2b60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b60 RCSB], [https://www.ebi.ac.uk/pdbsum/2b60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b60 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q7SMT3_9HIV1 Q7SMT3_9HIV1]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b6/2b60_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b60 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Agbandje-McKenna, M.]]
[[Category: Agbandje-McKenna M]]
[[Category: Clemente, J C.]]
[[Category: Clemente JC]]
[[Category: Desai, K A.]]
[[Category: Desai KA]]
[[Category: Dunn, B M.]]
[[Category: Dunn BM]]
[[Category: Goodenow, M M.]]
[[Category: Goodenow MM]]
[[Category: Govindasamy, L.]]
[[Category: Govindasamy L]]
[[Category: Janka, L K.]]
[[Category: Janka LK]]
[[Category: Jeung, J A.]]
[[Category: Jeung JA]]
[[Category: McKenna, R.]]
[[Category: McKenna R]]
[[Category: Stow, L R.]]
[[Category: Stow LR]]
[[Category: GOL]]
[[Category: RIT]]
[[Category: hiv-1 protease]]
[[Category: protease inhibitors]]
[[Category: protein-inhibitor complex]]
[[Category: ritonavir]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:34:34 2008''

Latest revision as of 12:16, 14 February 2024

Structure of HIV-1 protease mutant bound to RitonavirStructure of HIV-1 protease mutant bound to Ritonavir

Structural highlights

2b60 is a 2 chain structure with sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q7SMT3_9HIV1

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

2b60, resolution 2.20Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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