Factor XIII: Difference between revisions

Latest revision as of 12:38, 22 May 2018

Function

Factor XIII (FXIII) belongs to the blood coagulation system and crosslinks fibrin resulting in an insoluble clot. FXIII is activated by thrombin which cleaves it and releases an activation peptide^[1].

Disease

FXIII deficiency causes internal bleeding.

3D Structures of Factor XIII3D Structures of Factor XIII

Updated on 22-May-2018

1ggt – hFXIII - human
1ex0 – hFXIII zymogen (mutant)
1fie – hFXIII subunit A
1f13 - hFXIII zymogen subunit A dimer
4kty - hFXIII subunit A + peptide-like ligand
5mhl, 5mhm, 5mhn, 5mho - hFXIII subunit A (mutant) + peptide inhibitor
1ggy, 1qrk, 1ggu, 1evu – hFXIII + ion
1de7 – hFXIII activation peptide + α-thrombin

ReferencesReferences

↑ Laki K, Lorand L. On the Solubility of Fibrin Clots. Science. 1948 Sep 10;108(2802):280. PMID:17842715 doi:http://dx.doi.org/10.1126/science.108.2802.280

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

[1] Laki K, Lorand L. On the Solubility of Fibrin Clots. Science. 1948 Sep 10;108(2802):280. PMID:17842715 doi:http://dx.doi.org/10.1126/science.108.2802.280

[1]

@@ Line 1: / Line 1: @@
-[[Image:1ggt.png|left|200px|thumb|Crystal Structure of human Factor XIII, [[1ggt]]]]
+<StructureSection load='1ggt' size='350' side='right' caption='Human Factor XIII dimer (PDB entry [[1ggt]])' scene='Factor_XIII/Cv/1'>
-{{STRUCTURE_1ggt|  PDB=1ggt  | SIZE=300| SCENE=Factor_XIII/Cv/1 |right|CAPTION=Human Factor XIII dimer, [[1ggt]] }}
+== Function ==
-[[Factor XIII]] (FXIII) belongs to the blood coagulation system and crosslinks fibrin resulting in an insoluble clot.  FXIII is activated by thrombin which cleaves it and releases an activation peptide.  The images at the left and at the right correspond to one representative FXIII, ''i.e.'' the crystal structure of human Factor XIII ([[1ggt]]).
+[[Factor XIII]] (FXIII) belongs to the blood coagulation system and crosslinks fibrin resulting in an insoluble clot.  FXIII is activated by thrombin which cleaves it and releases an activation peptide<ref>PMID:17842715</ref>.
-{{TOC limit|limit=2}}
+== Disease ==
-<br />
-<br />
-<br />
-<br />
-<br />
+FXIII deficiency causes internal bleeding.
+</StructureSection>
 == 3D Structures of Factor XIII ==
@@ Line 18: / Line 15: @@
 [[1ex0]] – hFXIII zymogen (mutant)<br />
 [[1fie]] – hFXIII subunit A<br />
-[[1f13]] - hFXIII zymogen subunit A dimmer<br />
+[[1f13]] - hFXIII zymogen subunit A dimer<br />
+[[4kty]] - hFXIII subunit A + peptide-like ligand<br />
+[[5mhl]], [[5mhm]], [[5mhn]], [[5mho]] - hFXIII subunit A (mutant) + peptide inhibitor<br />
 [[1ggy]], [[1qrk]], [[1ggu]], [[1evu]] – hFXIII + ion<br />
-[[1de7]] – fFXIII activation peptide + α-thrombin<br />
+[[1de7]] – hFXIII activation peptide + α-thrombin<br />
+== References ==
+<references/>
 [[Category:Topic Page]]