Cruzain: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-<StructureSection load='1me3' size='400' side='right' caption='Structure of cruzain complex with methylketone inhibitor (PDB entry [[1me3]])' scene=''>
+<StructureSection load='1me3' size='350' side='right' caption='Structure of cruzain catalytic domain complex with methylketone inhibitor (PDB entry [[1me3]])' scene='51/517378/Cv/1'>
-'''Cruzain''' (Cru) is the major cysteine protease present in ''Trypanosoma cruzi'' which is the parasite causing Chagas disease.
+'''Cruzain''' or '''cruzipain''' (Cru) is the major cysteine protease present in ''Trypanosoma cruzi'' which is the parasite causing Chagas disease. <ref>PMID:10997902</ref>
+== Relevance ==
+Cru inhibitors are being investigated for therapeutic use against Chagas disease.
+== Structural highlights ==
+<scene name='51/517378/Cv/5'>Cru catalytic triad is Cys-His-Asn</scene> and <scene name='51/517378/Cv/6'>whole binding site</scene> ([[1me3]]).<ref>PMID:12467703</ref>
+</StructureSection>
 ==3D structures of cruzain==
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[1aim]], [[2aim]], [[1me3]], [[1me4]] –  Cru catalytic domain + methylketone inhibitor – ''Trypanosoma cruzi''<br />
+[[6n3s]] - TcCru catalytic domain 123-337 - ''Trypanosoma cruzi'' <br />
-[[1f29]], [[1f2a]], [[1f2b]], [[1f2c]], [[1ewo]], [[3lxs]] - Cru catalytic domain + vinyl sulfone derived inhibitor<br />
+[[1aim]], [[2aim]], [[1me3]], [[1me4]], [[3iut]] –  TcCru catalytic domain + methylketone inhibitor<br />
-[[1ewl]], [[1ewm]] – Cru catalytic domain + methylbutane inhibitor
+[[1f29]], [[1f2a]], [[1f2b]], [[1f2c]], [[1ewo]], [[2oz2]], [[3hd3]], [[3lxs]], [[6ux6]] - TcCru catalytic domain + vinyl sulfone derived inhibitor<br />
+[[1ewl]], [[1ewm]] – TcCru catalytic domain + methylbutane inhibitor<br />
+[[1u9q]], [[3i06]], [[3kku]], [[4klb]], [[4pi3]], [[4qh6]], [[4w5b]], [[4w5c]], [[4xui]], [[6o2x]] - TcCru catalytic domain + inhibitor<br />
+[[1ewp]] - TcCru catalytic domain + MOR-Leu-HPQ<br />
+[[4w5b]], [[4xui]], [[4qh6]], [[4pi3]], [[4klb]], [[3kku]], [[3i06]], [[2oz2]], [[1u9q]] – TcCru + inhibitor <br />
+[[4w5c]], [[3iut]], [[3hd3]] – TcCru (mutant) + inhibitor <br />
+[[7juj]], [[7s18]], [[7s19]] - TcCru catalytic domain + gallinamide derivative<br />
+== References ==
+<references/>
-</StructureSection>
+[[Category:Topic Page]]