CD44: Difference between revisions

Latest revision as of 11:31, 20 January 2025

Function

CD44 is a glycoprotein involved in cell-cell interactions. CD44 is a receptor of hyaluronic acid (HA). CD44 undergoes post-translational modification. Its sialofucosylation changes it to a form which directs migration of stem cells to bone marrow.^[1]

(2jcq).^[2]

Relevance

CD44 is a potential drug target for treatment of malignant neoplasms. Anti-CD44 antibody treatment lowers hyperglycemia and chronic inflammatory diseases.

Mouse CD44 hyaluronan-binding domain complex with glucuronic acid, NAG and ethylene glycerol (PDB code 2jcq)

Drag the structure with the mouse to rotate

3D structures of CD443D structures of CD44

Updated on 20-January-2025

1uuh, 4pz4 – hCD44 hyaluronan-binding domain 18-171 – human
1poz, 2i83 - hCD44 hyaluronan-binding domain – NMR
4pz3 - hCD44 hyaluronan-binding domain + tetrapeptide
2jcp - mCD44 hyaluronan-binding domain 23-172 – mouse
2jcq, 2jcr - mCD44 hyaluronan-binding domain + 8-mer HA
4mrd, 4mre, 4mrf, 4mrg, 4mrh, 4np2, , 4np3, 5bzc, 5bzk, 5sbk, 5sbl, 5sbm, 5sbn, 5sbo, 5sbp, 5sbq, 5sbr, 5sbs, 5sbt, 5sbu, 5sbv, 5sbw, 5sbx, 5sby, 5sbz, 5sc0, 5sc1, 5sc2, 5sc3, 5sc4, 5sc5, 5sc6, 5sc7 - mCD44 hyaluronan-binding domain + inhibitor
5bze, 5bzf, 5bzg, 5bzh, 5bzi, 5bzj, 5bzl, 5bzm, 5bzn, 5bzo, 5bzp, 5bzq, 5bzr, 5bzs, 5bzt - mCD44 hyaluronan-binding domain (mutant) + inhibitor
4np3 - mCD44 hyaluronan-binding domain + tetrapeptide

ReferencesReferences

↑ Liu LK, Finzel B. High-resolution crystal structures of alternate forms of the human CD44 hyaluronan-binding domain reveal a site for protein interaction. Acta Crystallogr F Struct Biol Commun. 2014 Sep 1;70(Pt 9):1155-61. doi:, 10.1107/S2053230X14015532. Epub 2014 Aug 29. PMID:25195884 doi:http://dx.doi.org/10.1107/S2053230X14015532
↑ Banerji S, Wright AJ, Noble M, Mahoney DJ, Campbell ID, Day AJ, Jackson DG. Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction. Nat Struct Mol Biol. 2007 Mar;14(3):234-9. Epub 2007 Feb 11. PMID:17293874 doi:10.1038/nsmb1201

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Liu LK, Finzel B. High-resolution crystal structures of alternate forms of the human CD44 hyaluronan-binding domain reveal a site for protein interaction. Acta Crystallogr F Struct Biol Commun. 2014 Sep 1;70(Pt 9):1155-61. doi:, 10.1107/S2053230X14015532. Epub 2014 Aug 29. PMID:25195884 doi:http://dx.doi.org/10.1107/S2053230X14015532

[2] Banerji S, Wright AJ, Noble M, Mahoney DJ, Campbell ID, Day AJ, Jackson DG. Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction. Nat Struct Mol Biol. 2007 Mar;14(3):234-9. Epub 2007 Feb 11. PMID:17293874 doi:10.1038/nsmb1201

[1]

[2]

@@ Line 1: / Line 1: @@
-<Structure load='2jcq' size='400' frame='true' align='right' caption='Structure of mouse CD44 hyaluronan-binding domain complex with 8-mer HA (PDB entry [[2jcq]])' scene='Insert optional scene name here' />
+<StructureSection load='2jcq' size='350' side='right' scene='' caption='Mouse CD44 hyaluronan-binding domain complex with glucuronic acid, NAG and ethylene glycerol (PDB code [[2jcq]])'>
-'''CD44''' is a glycoprotein involved in cell-cell interactions.  CD44 is a receptor of hyaluronic acid (HA).  CD44 undergoes post-translational modification.  Its sialofucosylation changes it to a form which directs migration of stem cells to bone marrow.
+== Function ==
+'''CD44''' is a glycoprotein involved in cell-cell interactions.  CD44 is a receptor of hyaluronic acid (HA).  CD44 undergoes post-translational modification.  Its sialofucosylation changes it to a form which directs migration of stem cells to bone marrow.<ref>PMID:25195884</ref>
+*<scene name='52/523368/Cv/4'>Binding site of CD44 hyaluronan-binding domain</scene> ([[2jcq]]).<ref>PMID:17293874</ref>
+== Relevance ==
+CD44 is a potential drug target for treatment of malignant neoplasms.  Anti-CD44 antibody treatment lowers hyperglycemia and chronic inflammatory diseases.
+</StructureSection>
 ==3D structures of CD44==
@@ Line 7: / Line 16: @@
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[1uuh]] – hCD44 hyaluronan-binding domain – human<br />
+[[1uuh]], [[4pz4]] – hCD44 hyaluronan-binding domain 18-171 – human<br />
 [[1poz]], [[2i83]] - hCD44 hyaluronan-binding domain – NMR<br />
-[[2jcp]] - mCD44 hyaluronan-binding domain – mouse<br />
+[[4pz3]] - hCD44 hyaluronan-binding domain + tetrapeptide<br /`>
-[[2jcq]], [[2jcr]] - mCD44 hyaluronan-binding domain + 8-mer HA
+[[2jcp]] - mCD44 hyaluronan-binding domain 23-172 – mouse<br />
+[[2jcq]], [[2jcr]] - mCD44 hyaluronan-binding domain + 8-mer HA<br />
+[[4mrd]], [[4mre]], [[4mrf]], [[4mrg]], [[4mrh]], [[4np2]], , [[4np3]], [[5bzc]], [[5bzk]], [[5sbk]], [[5sbl]], [[5sbm]], [[5sbn]], [[5sbo]], [[5sbp]], [[5sbq]], [[5sbr]], [[5sbs]], [[5sbt]], [[5sbu]], [[5sbv]], [[5sbw]], [[5sbx]], [[5sby]], [[5sbz]], [[5sc0]], [[5sc1]], [[5sc2]], [[5sc3]], [[5sc4]], [[5sc5]], [[5sc6]], [[5sc7]] - mCD44 hyaluronan-binding domain + inhibitor<br />
+[[5bze]], [[5bzf]], [[5bzg]], [[5bzh]], [[5bzi]], [[5bzj]], [[5bzl]], [[5bzm]], [[5bzn]], [[5bzo]], [[5bzp]], [[5bzq]], [[5bzr]], [[5bzs]], [[5bzt]] - mCD44 hyaluronan-binding domain (mutant) + inhibitor<br />
+[[4np3]] - mCD44 hyaluronan-binding domain + tetrapeptide<br />
+== References ==
+<references/>
 [[Category:Topic Page]]