4e1v: Difference between revisions

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-[[Image:4e1v.jpg|left|200px]]
-{{STRUCTURE_4e1v|  PDB=4e1v  |  SCENE=  }}
+==X-RAY Structure of the Uridine Phosphorylase from Salmonella Typhimurium in Complex with 5-Fluorouracil at 2.15 A Resolution==
+<StructureSection load='4e1v' size='340' side='right'caption='[[4e1v]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4e1v]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3nsr 3nsr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E1V FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=URF:5-FLUOROURACIL'>URF</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e1v OCA], [https://pdbe.org/4e1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e1v RCSB], [https://www.ebi.ac.uk/pdbsum/4e1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e1v ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/UDP_SALTY UDP_SALTY] Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity).
-===X-RAY Structure of the Uridine Phosphorylase from Salmonella Typhimurium in Complex with 5-Fluorouracil at 2.15 A Resolution===
+==See Also==
+*[[Uridine phosphorylase|Uridine phosphorylase]]
-{{ABSTRACT_PUBMED_22868762}}
+*[[Uridine phosphorylase 3D structures|Uridine phosphorylase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-[[4e1v]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium_str._lt2 Salmonella enterica subsp. enterica serovar typhimurium str. lt2]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3nsr 3nsr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E1V OCA].
+[[Category: Large Structures]]
+[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
-==Reference==
+[[Category: Gabdoulkhakov AG]]
-<ref group="xtra">PMID:019478441</ref><references group="xtra"/>
+[[Category: Lashkov AA]]
-[[Category: Salmonella enterica subsp. enterica serovar typhimurium str. lt2]]
+[[Category: Mikhailov AM]]
-[[Category: Uridine phosphorylase]]
+[[Category: Prokofev II]]
-[[Category: Gabdoulkhakov, A G.]]
+[[Category: Sotnichenko SE]]
-[[Category: Lashkov, A A.]]
-[[Category: Mikhailov, A M.]]
-[[Category: Prokofev, I I.]]
-[[Category: Sotnichenko, S E.]]
-[[Category: Drug metabolism]]
-[[Category: Rossmann fold]]
-[[Category: Transferase]]