4jgd: Difference between revisions

Latest revision as of 17:23, 8 November 2023

Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A016Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A016

Structural highlights

4jgd is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.05Å
Ligands:	, , , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

PYRD_HUMAN Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:263750; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.^[1]

Function

PYRD_HUMAN Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

References

↑ Ng SB, Buckingham KJ, Lee C, Bigham AW, Tabor HK, Dent KM, Huff CD, Shannon PT, Jabs EW, Nickerson DA, Shendure J, Bamshad MJ. Exome sequencing identifies the cause of a mendelian disorder. Nat Genet. 2010 Jan;42(1):30-5. doi: 10.1038/ng.499. Epub 2009 Nov 13. PMID:19915526 doi:10.1038/ng.499

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OCA

[1] Ng SB, Buckingham KJ, Lee C, Bigham AW, Tabor HK, Dent KM, Huff CD, Shannon PT, Jabs EW, Nickerson DA, Shendure J, Bamshad MJ. Exome sequencing identifies the cause of a mendelian disorder. Nat Genet. 2010 Jan;42(1):30-5. doi: 10.1038/ng.499. Epub 2009 Nov 13. PMID:19915526 doi:10.1038/ng.499

[1]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4jgd is ON HOLD
+==Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A016==
+<StructureSection load='4jgd' size='340' side='right'caption='[[4jgd]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4jgd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JGD FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4JG:1-[4-METHYL-2-(NAPHTHALEN-2-YLAMINO)-1,3-THIAZOL-5-YL]ETHANONE'>4JG</scene>, <scene name='pdbligand=DET:UNDECYLAMINE-N,N-DIMETHYL-N-OXIDE'>DET</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jgd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jgd OCA], [https://pdbe.org/4jgd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jgd RCSB], [https://www.ebi.ac.uk/pdbsum/4jgd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jgd ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
-Authors: Zhu, L.L., Zhu, J.S., Ren, X.L.
+==See Also==
+*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
-Description: Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A016
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Li H]]
+[[Category: Ren X]]
+[[Category: Zhu J]]
+[[Category: Zhu L]]

4jgd: Difference between revisions

Latest revision as of 17:23, 8 November 2023

Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A016Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A016

Structural highlights

Disease

Function

See Also

References

Contents

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4jgd: Difference between revisions

Latest revision as of 17:23, 8 November 2023

Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A016Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A016

Structural highlights

Disease

Function

See Also

References

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