3gs3: Difference between revisions

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[[Image:3gs3.png|left|200px]]


{{STRUCTURE_3gs3| PDB=3gs3 | SCENE= }}
==Structure of the N-terminal HEAT Domain of Symplekin from D. melanogaster==
<StructureSection load='3gs3' size='340' side='right'caption='[[3gs3]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3gs3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GS3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gs3 OCA], [https://pdbe.org/3gs3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gs3 RCSB], [https://www.ebi.ac.uk/pdbsum/3gs3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gs3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SYMPK_DROME SYMPK_DROME] Component of a protein complex required for cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA.<ref>PMID:18042462</ref> <ref>PMID:19450530</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gs/3gs3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gs3 ConSurf].
<div style="clear:both"></div>


===Structure of the N-terminal HEAT Domain of Symplekin from D. melanogaster===
==See Also==
 
*[[Symplekin|Symplekin]]
{{ABSTRACT_PUBMED_19576221}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[3gs3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GS3 OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:019576221</ref><references group="xtra"/>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Kennedy, S A.]]
[[Category: Large Structures]]
[[Category: Redinbo, M R.]]
[[Category: Kennedy SA]]
[[Category: Helix-turn-helix heat repeat extended loop]]
[[Category: Redinbo MR]]
[[Category: Protein binding]]
[[Category: Transcription]]

Latest revision as of 12:56, 21 February 2024

Structure of the N-terminal HEAT Domain of Symplekin from D. melanogasterStructure of the N-terminal HEAT Domain of Symplekin from D. melanogaster

Structural highlights

3gs3 is a 1 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SYMPK_DROME Component of a protein complex required for cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Wagner EJ, Burch BD, Godfrey AC, Salzler HR, Duronio RJ, Marzluff WF. A genome-wide RNA interference screen reveals that variant histones are necessary for replication-dependent histone pre-mRNA processing. Mol Cell. 2007 Nov 30;28(4):692-9. PMID:18042462 doi:10.1016/j.molcel.2007.10.009
  2. ↑ Sullivan KD, Steiniger M, Marzluff WF. A core complex of CPSF73, CPSF100, and Symplekin may form two different cleavage factors for processing of poly(A) and histone mRNAs. Mol Cell. 2009 May 15;34(3):322-32. doi: 10.1016/j.molcel.2009.04.024. PMID:19450530 doi:10.1016/j.molcel.2009.04.024

3gs3, resolution 2.40Å

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OCA
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