4j5w: Difference between revisions
New page: '''Unreleased structure''' The entry 4j5w is ON HOLD Authors: Wallace, B.D., Betts, L., Redinbo, M.R. Description: Crystal Structure of the apo-PXR/RXRalpha LBD Heterotetramer Complex |
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==Crystal Structure of the apo-PXR/RXRalpha LBD Heterotetramer Complex== | |||
<StructureSection load='4j5w' size='340' side='right'caption='[[4j5w]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4j5w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J5W FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j5w OCA], [https://pdbe.org/4j5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j5w RCSB], [https://www.ebi.ac.uk/pdbsum/4j5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j5w ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NR1I2_HUMAN NR1I2_HUMAN] Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.<ref>PMID:9727070</ref> <ref>PMID:11668216</ref> <ref>PMID:11297522</ref> <ref>PMID:19297428</ref> <ref>PMID:12578355</ref> <ref>PMID:18768384</ref> | |||
==See Also== | |||
*[[Pregnane X receptor 3D structures|Pregnane X receptor 3D structures]] | |||
*[[Retinoid X receptor 3D structures|Retinoid X receptor 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Betts L]] | |||
[[Category: Redinbo MR]] | |||
[[Category: Wallace BD]] | |||