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[[Image:1ixx.gif|left|200px]]<br />
<applet load="1ixx" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1ixx, resolution 2.5&Aring;" />
'''CRYSTAL STRUCTURE OF COAGULATION FACTORS IX/X-BINDING PROTEIN (IX/X-BP) FROM VENOM OF HABU SNAKE WITH A HETERODIMER OF C-TYPE LECTIN DOMAINS'''<br />


==Overview==
==CRYSTAL STRUCTURE OF COAGULATION FACTORS IX/X-BINDING PROTEIN (IX/X-BP) FROM VENOM OF HABU SNAKE WITH A HETERODIMER OF C-TYPE LECTIN DOMAINS==
Coagulation factors IX/X-binding protein is an intertwined dimer with a, central loop projecting into the adjoining subunit. Excluding this loop, each subunit has a fold similar to rat mannose-binding protein.
<StructureSection load='1ixx' size='340' side='right'caption='[[1ixx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ixx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Protobothrops_flavoviridis Protobothrops flavoviridis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IXX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ixx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ixx OCA], [https://pdbe.org/1ixx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ixx RCSB], [https://www.ebi.ac.uk/pdbsum/1ixx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ixx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SL9A_PROFL SL9A_PROFL] Anticoagulant protein which binds to the gamma-carboxyglutamic acid-domain regions of factors IX (F9) and factor X (F10) in the presence of calcium with a 1 to 1 stoichiometry.<ref>PMID:2613688</ref> <ref>PMID:7925387</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/1ixx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ixx ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Coagulation factors IX/X-binding protein is an intertwined dimer with a central loop projecting into the adjoining subunit. Excluding this loop, each subunit has a fold similar to rat mannose-binding protein.


==About this Structure==
Structure of coagulation factors IX/X-binding protein, a heterodimer of C-type lectin domains.,Mizuno H, Fujimoto Z, Koizumi M, Kano H, Atoda H, Morita T Nat Struct Biol. 1997 Jun;4(6):438-41. PMID:9187649<ref>PMID:9187649</ref>
1IXX is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Trimeresurus_flavoviridis Trimeresurus flavoviridis]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Sites: S1, S2, S3, S4, S5 and S6. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IXX OCA]].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Structure of coagulation factors IX/X-binding protein, a heterodimer of C-type lectin domains., Mizuno H, Fujimoto Z, Koizumi M, Kano H, Atoda H, Morita T, Nat Struct Biol. 1997 Jun;4(6):438-41. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9187649 9187649]
</div>
[[Category: Protein complex]]
<div class="pdbe-citations 1ixx" style="background-color:#fffaf0;"></div>
[[Category: Trimeresurus flavoviridis]]
== References ==
[[Category: Fujimoto, Z.]]
<references/>
[[Category: Kano, H.]]
__TOC__
[[Category: Koizumi, M.]]
</StructureSection>
[[Category: Mizuno, H.]]
[[Category: Large Structures]]
[[Category: CA]]
[[Category: Protobothrops flavoviridis]]
[[Category: c-type crd motif]]
[[Category: Fujimoto Z]]
[[Category: c-type lectin]]
[[Category: Kano H]]
[[Category: coagulation factor binding]]
[[Category: Koizumi M]]
[[Category: gla-domain binding]]
[[Category: Mizuno H]]
[[Category: loop exchanged dimer]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:40:09 2007''

Latest revision as of 09:47, 30 October 2024

CRYSTAL STRUCTURE OF COAGULATION FACTORS IX/X-BINDING PROTEIN (IX/X-BP) FROM VENOM OF HABU SNAKE WITH A HETERODIMER OF C-TYPE LECTIN DOMAINSCRYSTAL STRUCTURE OF COAGULATION FACTORS IX/X-BINDING PROTEIN (IX/X-BP) FROM VENOM OF HABU SNAKE WITH A HETERODIMER OF C-TYPE LECTIN DOMAINS

Structural highlights

1ixx is a 6 chain structure with sequence from Protobothrops flavoviridis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SL9A_PROFL Anticoagulant protein which binds to the gamma-carboxyglutamic acid-domain regions of factors IX (F9) and factor X (F10) in the presence of calcium with a 1 to 1 stoichiometry.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Coagulation factors IX/X-binding protein is an intertwined dimer with a central loop projecting into the adjoining subunit. Excluding this loop, each subunit has a fold similar to rat mannose-binding protein.

Structure of coagulation factors IX/X-binding protein, a heterodimer of C-type lectin domains.,Mizuno H, Fujimoto Z, Koizumi M, Kano H, Atoda H, Morita T Nat Struct Biol. 1997 Jun;4(6):438-41. PMID:9187649[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

  1. ↑ Atoda H, Morita T. A novel blood coagulation factor IX/factor X-binding protein with anticoagulant activity from the venom of Trimeresurus flavoviridis (Habu snake): isolation and characterization. J Biochem. 1989 Nov;106(5):808-13. PMID:2613688
  2. ↑ Atoda H, Yoshida N, Ishikawa M, Morita T. Binding properties of the coagulation factor IX/factor X-binding protein isolated from the venom of Trimeresurus flavoviridis. Eur J Biochem. 1994 Sep 1;224(2):703-8. PMID:7925387
  3. ↑ Mizuno H, Fujimoto Z, Koizumi M, Kano H, Atoda H, Morita T. Structure of coagulation factors IX/X-binding protein, a heterodimer of C-type lectin domains. Nat Struct Biol. 1997 Jun;4(6):438-41. PMID:9187649

1ixx, resolution 2.50Å

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