4idl: Difference between revisions

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-[[Image:4idl.jpg|left|200px]]
-{{STRUCTURE_4idl|  PDB=4idl  |  SCENE=  }}
+==Low melting temperature Anti-Cholera Toxin Llama VHH domain==
+<StructureSection load='4idl' size='340' side='right'caption='[[4idl]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4idl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IDL FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4idl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4idl OCA], [https://pdbe.org/4idl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4idl RCSB], [https://www.ebi.ac.uk/pdbsum/4idl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4idl ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Variable heavy domains derived from the heavy-chain-only antibodies found in camelids (V(H)H domains) are known for their thermal stability. Here, the structure of A9, an anti-cholera toxin V(H)H domain (K(d) = 77 +/- 5 nM) that has an unusually low melting temperature of 319.9 +/- 1.6 K, is reported. The CDR3 residues of A9 form a beta-hairpin that is directed away from the former V(H)-V(L) interfacial surface, exposing hydrophobic residues to the solvent. A DALI structural similarity search showed that this CDR3 conformation is uncommon.
-===Low melting temperature Anti-Cholera Toxin Llama VHH domain===
+Structure of a low-melting-temperature anti-cholera toxin: llama V(H)H domain.,Legler PM, Zabetakis D, Anderson GP, Lam A, Hol WG, Goldman ER Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Feb 1;69(Pt 2):90-3. doi: , 10.1107/S1744309112050750. Epub 2013 Jan 26. PMID:23385744<ref>PMID:23385744</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 4idl" style="background-color:#fffaf0;"></div>
-==About this Structure==
+==See Also==
-[[4idl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IDL OCA].
+*[[Antibody 3D structures|Antibody 3D structures]]
+*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
+*[[3D structures of non-human antibody|3D structures of non-human antibody]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Lama glama]]
-[[Category: Hol, W G.J.]]
+[[Category: Large Structures]]
-[[Category: Lam, A.]]
+[[Category: Hol WGJ]]
-[[Category: Legler, P M.]]
+[[Category: Lam A]]
-[[Category: Antibody]]
+[[Category: Legler PM]]
-[[Category: Cholera toxin]]
-[[Category: Immune system]]
-[[Category: Single domain antibody]]
-[[Category: V-type immunoglobin fold]]