4j34: Difference between revisions

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'''Unreleased structure'''


The entry 4j34 is ON HOLD
==Crystal Structure of kynurenine 3-monooxygenase - truncated at position 394 plus HIS tag cleaved.==
<StructureSection load='4j34' size='340' side='right'caption='[[4j34]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4j34]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J34 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j34 OCA], [https://pdbe.org/4j34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j34 RCSB], [https://www.ebi.ac.uk/pdbsum/4j34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j34 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KMO_YEAST KMO_YEAST] Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.<ref>PMID:12062417</ref> <ref>PMID:15806102</ref>


Authors: Amaral, M., Levy, C., Heyes, D.J., Lafite, P., Outeiro, T.F., Giorgini, F., Leys, D., Scrutton, N.S.
==See Also==
 
*[[Monooxygenase 3D structures|Monooxygenase 3D structures]]
Description: Crystal Structure of kynurenine 3-monooxygenase -truncated at position 394 plus HIS tag cleaved.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Amaral M]]
[[Category: Giorgini F]]
[[Category: Heyes DJ]]
[[Category: Lafite P]]
[[Category: Levy C]]
[[Category: Leys D]]
[[Category: Outeiro TF]]
[[Category: Scrutton NS]]

Latest revision as of 15:00, 1 March 2024

Crystal Structure of kynurenine 3-monooxygenase - truncated at position 394 plus HIS tag cleaved.Crystal Structure of kynurenine 3-monooxygenase - truncated at position 394 plus HIS tag cleaved.

Structural highlights

4j34 is a 2 chain structure with sequence from Saccharomyces cerevisiae S288C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.03Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KMO_YEAST Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.[1] [2]

See Also

References

  1. ↑ Panozzo C, Nawara M, Suski C, Kucharczyka R, Skoneczny M, Becam AM, Rytka J, Herbert CJ. Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae. FEBS Lett. 2002 Apr 24;517(1-3):97-102. PMID:12062417
  2. ↑ Giorgini F, Guidetti P, Nguyen Q, Bennett SC, Muchowski PJ. A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Nat Genet. 2005 May;37(5):526-31. Epub 2005 Apr 3. PMID:15806102 doi:ng1542

4j34, resolution 2.03Å

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