3emi: Difference between revisions

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-[[Image:3emi.png|left|200px]]
-{{STRUCTURE_3emi|  PDB=3emi  |  SCENE=  }}
+==Crystal structure of Hia 307-422 non-adhesive domain==
+<StructureSection load='3emi' size='340' side='right'caption='[[3emi]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3emi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EMI FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3emi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3emi OCA], [https://pdbe.org/3emi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3emi RCSB], [https://www.ebi.ac.uk/pdbsum/3emi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3emi ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q48152_HAEIF Q48152_HAEIF]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/em/3emi_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3emi ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The Hia autotransporter of Haemophilus influenzae belongs to the trimeric autotransporter subfamily and mediates bacterial adherence to the respiratory epithelium. In this report, we show that the structure of Hia is characterized by a modular architecture containing repeats of structurally distinct domains. Comparison of the structures of HiaBD1 and HiaBD2 adhesive repeats and a nonadhesive repeat (a novel fold) shed light on the structural determinants of Hia adhesive function. Examination of the structure of an extended version of the Hia translocator domain revealed the structural transition between the C-terminal translocator domain and the N-terminal passenger domain, highlighting a highly intertwined domain that is ubiquitous among trimeric autotransporters. Overall, this study provides important insights into the mechanism of Hia adhesive activity and the overall structure of trimeric autotransporters.
-===Crystal structure of Hia 307-422 non-adhesive domain===
+Repetitive architecture of the Haemophilus influenzae Hia trimeric autotransporter.,Meng G, St Geme JW 3rd, Waksman G J Mol Biol. 2008 Dec 26;384(4):824-36. Epub 2008 Oct 11. PMID:18948113<ref>PMID:18948113</ref>
-{{ABSTRACT_PUBMED_18948113}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3emi" style="background-color:#fffaf0;"></div>
-==About this Structure==
+==See Also==
-[[3emi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EMI OCA].
+*[[Adhesin 3D structures|Adhesin 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:018948113</ref><references group="xtra"/>
+__TOC__
-[[Category: Haemophilus influenzae]]
+</StructureSection>
-[[Category: Meng, G.]]
-[[Category: Waksman, G.]]
-[[Category: Cell adhesion]]
 [[Category: Haemophilus influenzae]]
-[[Category: Hia adhesin]]
+[[Category: Large Structures]]
-[[Category: Non-adhesive domain]]
+[[Category: Meng G]]
-[[Category: Trimeric autotransporter]]
+[[Category: Waksman G]]