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[[Image:4ihc.jpg|left|200px]]


{{STRUCTURE_4ihc|  PDB=4ihc  |  SCENE=  }}
==Crystal structure of probable mannonate dehydratase Dd703_0947 (target EFI-502222) from Dickeya dadantii Ech703==
 
<StructureSection load='4ihc' size='340' side='right'caption='[[4ihc]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
===Crystal structure of probable mannonate dehydratase Dd703_0947 (target EFI-502222) from Dickeya dadantii Ech703===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4ihc]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Musicola_paradisiaca_Ech703 Musicola paradisiaca Ech703]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IHC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IHC FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[4ihc]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Dickeya_dadantii_ech703 Dickeya dadantii ech703]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IHC OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ihc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ihc OCA], [https://pdbe.org/4ihc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ihc RCSB], [https://www.ebi.ac.uk/pdbsum/4ihc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ihc ProSAT]</span></td></tr>
[[Category: Dickeya dadantii ech703]]
</table>
[[Category: Almo, S C.]]
== Function ==
[[Category: Bhosle, R.]]
[https://www.uniprot.org/uniprot/DMGD_MUSP7 DMGD_MUSP7] Has low dehydratase activity with D-mannonate and D-gluconate, suggesting that these are not physiological substrates and that it has no significant role in the in vivo degradation of these compounds. Has no detectable activity with a panel of 70 other acid sugars (in vitro).<ref>PMID:24697546</ref>
[[Category: Chowdhury, S.]]
== References ==
[[Category: EFI, Enzyme Function Initiative.]]
<references/>
[[Category: Evans, B.]]
__TOC__
[[Category: Gerlt, J A.]]
</StructureSection>
[[Category: Glenn, A Scott.]]
[[Category: Large Structures]]
[[Category: Hammonds, J.]]
[[Category: Musicola paradisiaca Ech703]]
[[Category: Hillerich, B.]]
[[Category: Al Obaidi NF]]
[[Category: Imker, H J.]]
[[Category: Almo SC]]
[[Category: Love, J.]]
[[Category: Bhosle R]]
[[Category: Obaidi, N F.Al.]]
[[Category: Chowdhury S]]
[[Category: Patskovsky, Y.]]
[[Category: Evans B]]
[[Category: Seidel, R D.]]
[[Category: Gerlt JA]]
[[Category: Stead, M.]]
[[Category: Hammonds J]]
[[Category: Toro, R.]]
[[Category: Hillerich B]]
[[Category: Washington, E.]]
[[Category: Imker HJ]]
[[Category: Zencheck, W D.]]
[[Category: Love J]]
[[Category: Dehydratase]]
[[Category: Patskovsky Y]]
[[Category: Efi]]
[[Category: Scott Glenn A]]
[[Category: Enzyme function initiative]]
[[Category: Seidel RD]]
[[Category: Isomerase]]
[[Category: Stead M]]
[[Category: Magnesium binding]]
[[Category: Toro R]]
[[Category: Structural genomic]]
[[Category: Washington E]]
[[Category: Zencheck WD]]

Latest revision as of 18:23, 20 September 2023

Crystal structure of probable mannonate dehydratase Dd703_0947 (target EFI-502222) from Dickeya dadantii Ech703Crystal structure of probable mannonate dehydratase Dd703_0947 (target EFI-502222) from Dickeya dadantii Ech703

Structural highlights

4ihc is a 8 chain structure with sequence from Musicola paradisiaca Ech703. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DMGD_MUSP7 Has low dehydratase activity with D-mannonate and D-gluconate, suggesting that these are not physiological substrates and that it has no significant role in the in vivo degradation of these compounds. Has no detectable activity with a panel of 70 other acid sugars (in vitro).[1]

References

  1. ↑ Wichelecki DJ, Balthazor BM, Chau AC, Vetting MW, Fedorov AA, Fedorov EV, Lukk T, Patskovsky YV, Stead MB, Hillerich BS, Seidel RD, Almo SC, Gerlt JA. Discovery of function in the enolase superfamily: D-mannonate and d-gluconate dehydratases in the D-mannonate dehydratase subgroup. Biochemistry. 2014 Apr 29;53(16):2722-31. doi: 10.1021/bi500264p. Epub 2014 Apr, 15. PMID:24697546 doi:http://dx.doi.org/10.1021/bi500264p

4ihc, resolution 2.00Å

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