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[[Image:2qpw.png|left|200px]]


{{STRUCTURE_2qpw|  PDB=2qpw  |  SCENE=  }}
==Methyltransferase domain of human PR domain-containing protein 2==
 
<StructureSection load='2qpw' size='340' side='right'caption='[[2qpw]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
===Methyltransferase domain of human PR domain-containing protein 2===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2qpw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QPW FirstGlance]. <br>
{{ABSTRACT_PUBMED_20084102}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qpw OCA], [https://pdbe.org/2qpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qpw RCSB], [https://www.ebi.ac.uk/pdbsum/2qpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qpw ProSAT]</span></td></tr>
==About this Structure==
</table>
[[2qpw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QPW OCA].  
== Function ==
 
[https://www.uniprot.org/uniprot/PRDM2_HUMAN PRDM2_HUMAN] S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.<ref>PMID:14633678</ref>  
==Reference==
== Evolutionary Conservation ==
<ref group="xtra">PMID:020084102</ref><references group="xtra"/>
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qp/2qpw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qpw ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Antoshenko, T.]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Antoshenko T]]
[[Category: Bochkarev, A.]]
[[Category: Arrowsmith CH]]
[[Category: Dombrovski, L.]]
[[Category: Bochkarev A]]
[[Category: Edwards, A M.]]
[[Category: Dombrovski L]]
[[Category: Loppnau, P.]]
[[Category: Edwards AM]]
[[Category: Lunin, V V.]]
[[Category: Loppnau P]]
[[Category: Min, J.]]
[[Category: Lunin VV]]
[[Category: Plotnikov, A N.]]
[[Category: Min J]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Plotnikov AN]]
[[Category: Sundstrom, M.]]
[[Category: Sundstrom M]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Wu, H.]]
[[Category: Wu H]]
[[Category: Activator]]
[[Category: Alternative initiation]]
[[Category: Dna-binding]]
[[Category: Metal-binding]]
[[Category: Methyltransferase]]
[[Category: Nucleus]]
[[Category: Phosphorylation]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Zinc-finger]]

Latest revision as of 12:17, 21 February 2024

Methyltransferase domain of human PR domain-containing protein 2Methyltransferase domain of human PR domain-containing protein 2

Structural highlights

2qpw is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.79Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PRDM2_HUMAN S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Kim KC, Geng L, Huang S. Inactivation of a histone methyltransferase by mutations in human cancers. Cancer Res. 2003 Nov 15;63(22):7619-23. PMID:14633678

2qpw, resolution 1.79Å

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