2rol: Difference between revisions

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[[Image:2rol.png|left|200px]]


{{STRUCTURE_2rol|  PDB=2rol  |  SCENE=  }}
==Structural Basis of PxxDY motif recognition in SH3 binding==
 
<StructureSection load='2rol' size='340' side='right'caption='[[2rol]]' scene=''>
===Structural Basis of PxxDY motif recognition in SH3 binding===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2rol]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ROL FirstGlance]. <br>
{{ABSTRACT_PUBMED_18644376}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rol OCA], [https://pdbe.org/2rol PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rol RCSB], [https://www.ebi.ac.uk/pdbsum/2rol PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rol ProSAT]</span></td></tr>
==About this Structure==
</table>
[[2rol]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROL OCA].  
== Function ==
 
[https://www.uniprot.org/uniprot/ES8L1_HUMAN ES8L1_HUMAN] Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.<ref>PMID:14565974</ref>  
==Reference==
== Evolutionary Conservation ==
<ref group="xtra">PMID:018644376</ref><references group="xtra"/>
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ro/2rol_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rol ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Aitio, O.]]
[[Category: Large Structures]]
[[Category: Hellman, M.]]
[[Category: Aitio O]]
[[Category: Kesti, T.]]
[[Category: Hellman M]]
[[Category: Kleino, I.]]
[[Category: Kesti T]]
[[Category: Paakkonen, K.]]
[[Category: Kleino I]]
[[Category: Permi, P.]]
[[Category: Paakkonen K]]
[[Category: Saksela, K.]]
[[Category: Permi P]]
[[Category: Samuilova, O.]]
[[Category: Saksela K]]
[[Category: Tossavainen, H.]]
[[Category: Samuilova O]]
[[Category: Cd3e]]
[[Category: Tossavainen H]]
[[Category: Complex structure]]
[[Category: Eps8l1]]
[[Category: Immunoglobulin domain]]
[[Category: Membrane]]
[[Category: Phosphoprotein]]
[[Category: Receptor]]
[[Category: Sh3]]
[[Category: Sh3 domain]]
[[Category: Splicing-signaling protein complex]]
[[Category: Transmembrane]]

Latest revision as of 10:05, 1 May 2024

Structural Basis of PxxDY motif recognition in SH3 bindingStructural Basis of PxxDY motif recognition in SH3 binding

Structural highlights

2rol is a 2 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ES8L1_HUMAN Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Offenhauser N, Borgonovo A, Disanza A, Romano P, Ponzanelli I, Iannolo G, Di Fiore PP, Scita G. The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway. Mol Biol Cell. 2004 Jan;15(1):91-8. Epub 2003 Oct 17. PMID:14565974 doi:http://dx.doi.org/10.1091/mbc.E03-06-0427
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OCA
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