1wsb: Difference between revisions

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-[[Image:1wsb.gif|left|200px]]<br /><applet load="1wsb" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="1wsb, resolution 1.80&Aring;" />
-'''FLAVODOXIN MUTANT- S64C'''<br />
-==About this Structure==
+==Flavodoxin mutant- S64C==
-WSB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_vulgaris Desulfovibrio vulgaris] with <scene name='pdbligand=FMN:'>FMN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WSB OCA].
+<StructureSection load='1wsb' size='340' side='right'caption='[[1wsb]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1wsb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Desulfovibrio_vulgaris Desulfovibrio vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WSB FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wsb OCA], [https://pdbe.org/1wsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wsb RCSB], [https://www.ebi.ac.uk/pdbsum/1wsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wsb ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FLAV_DESVH FLAV_DESVH] Low-potential electron donor to a number of redox enzymes.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ws/1wsb_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wsb ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The mutant S64C of the short-chain flavodoxin from Desulfovibrio vulgaris has been designed to introduce an accessible and reactive group on the protein surface. Crystals have been obtained of both the monomeric and homodimeric forms of the protein, with the cofactor FMN in either the oxidized or the one electron-reduced (semiquinone) state, and the structures have been determined to high resolution. The redox properties of the different species have been investigated and the variations observed with respect to wild type have been related to the structural changes induced by the mutation and S-S bridge formation.
+Redox properties and crystal structures of a Desulfovibrio vulgaris flavodoxin mutant in the monomeric and homodimeric forms.,Fantuzzi A, Artali R, Bombieri G, Marchini N, Meneghetti F, Gilardi G, Sadeghi SJ, Cavazzini D, Rossi GL Biochim Biophys Acta. 2009 Mar;1794(3):496-505. Epub 2008 Dec 11. PMID:19118653<ref>PMID:19118653</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1wsb" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Flavodoxin 3D structures|Flavodoxin 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Desulfovibrio vulgaris]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Artali, R.]]
+[[Category: Artali R]]
-[[Category: Bombieri, G.]]
+[[Category: Bombieri G]]
-[[Category: Cavazzini, D.]]
+[[Category: Cavazzini D]]
-[[Category: Gilardi, G.]]
+[[Category: Gilardi G]]
-[[Category: Marchini, N.]]
+[[Category: Marchini N]]
-[[Category: Meneghetti, F.]]
+[[Category: Meneghetti F]]
-[[Category: Rossi, G L.]]
+[[Category: Rossi GL]]
-[[Category: FMN]]
-[[Category: flavodoxin monomer]]
-[[Category: mutant]]
-[[Category: redox protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:47:38 2008''