2g7r: Difference between revisions
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==X-ray structure of the death domain of the human mucosa associated lymphoid tissue lymphoma translocation protein 1== | |||
<StructureSection load='2g7r' size='340' side='right'caption='[[2g7r]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2g7r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G7R FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g7r OCA], [https://pdbe.org/2g7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g7r RCSB], [https://www.ebi.ac.uk/pdbsum/2g7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g7r ProSAT]</span></td></tr> | ||
[[2g7r]] is a 2 chain structure with sequence from [ | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN] Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN] Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.<ref>PMID:11262391</ref> <ref>PMID:14695475</ref> <ref>PMID:18264101</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g7/2g7r_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g7r ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: Bochkarev | [[Category: Arrowsmith C]] | ||
[[Category: Butler-Cole | [[Category: Bochkarev A]] | ||
[[Category: Dhe-Paganon | [[Category: Butler-Cole C]] | ||
[[Category: Edwards | [[Category: Dhe-Paganon S]] | ||
[[Category: Finerty | [[Category: Edwards A]] | ||
[[Category: Newman | [[Category: Finerty Jr PJ]] | ||
[[Category: Newman EM]] | |||
[[Category: Sundstrom | [[Category: Sundstrom M]] | ||
[[Category: Walker | [[Category: Walker JR]] | ||
[[Category: Weigelt | [[Category: Weigelt J]] | ||
[[Category: Wybenga-Groot | [[Category: Wybenga-Groot L]] | ||