2o2h: Difference between revisions

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-[[Image:2o2h.png|left|200px]]
-{{STRUCTURE_2o2h|  PDB=2o2h  |  SCENE=  }}
+==Crystal structure of haloalkane dehalogenase Rv2579 from Mycobacterium tuberculosis complexed with 1,2-dichloroethane==
+<StructureSection load='2o2h' size='340' side='right'caption='[[2o2h]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2o2h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O2H FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DCE:1,2-DICHLOROETHANE'>DCE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2h OCA], [https://pdbe.org/2o2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o2h RCSB], [https://www.ebi.ac.uk/pdbsum/2o2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o2h ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DHAA_MYCTU DHAA_MYCTU] Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity).[HAMAP-Rule:MF_01231]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o2/2o2h_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o2h ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of haloalkane dehalogenase Rv2579 from Mycobacterium tuberculosis complexed with 1,2-dichloroethane===
+==See Also==
+*[[Dehalogenase 3D structures|Dehalogenase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-[[2o2h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2H OCA].
+[[Category: Large Structures]]
-[[Category: Haloalkane dehalogenase]]
+[[Category: Mycobacterium tuberculosis H37Rv]]
-[[Category: Mycobacterium tuberculosis]]
+[[Category: Cherney MM]]
-[[Category: Cherney, M M.]]
+[[Category: Garen CR]]
-[[Category: Garen, C R.]]
+[[Category: Hulecki J]]
-[[Category: Hulecki, J.]]
+[[Category: James MNG]]
-[[Category: James, M N.G.]]
+[[Category: Mazumdar PA]]
-[[Category: Mazumdar, P A.]]
-[[Category: TBSGC, TB Structural Genomics Consortium.]]
-[[Category: 2-dichloroethane]]
-[[Category: Alpha/beta-hydrolase protein]]
-[[Category: Haloalkane dehalogenase]]
-[[Category: Hydrolase]]
-[[Category: Mycobacterium tuberculosis]]
-[[Category: Rv2579]]
-[[Category: Tb structural genomics consortium]]
-[[Category: Tbsgc]]