2eaw: Difference between revisions

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-[[Image:2eaw.png|left|200px]]
+==Human UMP Synthase (C-terminal Domain- Orotidine 5'-Monophosphate Decarboxylase)==
+<StructureSection load='2eaw' size='340' side='right' caption='[[2eaw]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
-{{STRUCTURE_2eaw|  PDB=2eaw  |  SCENE=  }}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2eaw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EAW FirstGlance]. <br>
-===Human UMP Synthase (C-terminal Domain- Orotidine 5'-Monophosphate Decarboxylase)===
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UMPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eaw OCA], [http://pdbe.org/2eaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eaw RCSB], [http://www.ebi.ac.uk/pdbsum/2eaw PDBsum]</span></td></tr>
-==About this Structure==
+</table>
-[[2eaw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAW OCA].
+== Disease ==
+[[http://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/2eaw_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eaw ConSurf].
+<div style="clear:both"></div>
 ==See Also==
 *[[Uridine 5'-monophosphate synthase|Uridine 5'-monophosphate synthase]]
-[[Category: Homo sapiens]]
+== References ==
-[[Category: Liu, Y.]]
+<references/>
-[[Category: Pai, E F.]]
+__TOC__
-[[Category: Tang, H L.]]
+</StructureSection>
+[[Category: Human]]
+[[Category: Liu, Y]]
+[[Category: Pai, E F]]
+[[Category: Tang, H L]]
 [[Category: C-terminal domain]]
-[[Category: Human]]
 [[Category: Lyase]]
 [[Category: Orotidine 5'-monophosphate decarboxylase]]
 [[Category: Ump synthase]]