2a59: Difference between revisions

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{{STRUCTURE_2a59|  PDB=2a59  |  SCENE=  }}
==Structure of 6,7-Dimethyl-8-ribityllumazine synthase from Schizosaccharomyces pombe mutant W27Y with bound ligand 5-nitroso-6-ribitylamino-2,4(1H,3H)-pyrimidinedione==
 
<StructureSection load='2a59' size='340' side='right'caption='[[2a59]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
===Structure of 6,7-Dimethyl-8-ribityllumazine synthase from Schizosaccharomyces pombe mutant W27Y with bound ligand 5-nitroso-6-ribitylamino-2,4(1H,3H)-pyrimidinedione===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2a59]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A59 FirstGlance]. <br>
{{ABSTRACT_PUBMED_15265040}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMZ:5-NITROSO-6-RIBITYL-AMINO-2,4(1H,3H)-PYRIMIDINEDIONE'>LMZ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a59 OCA], [https://pdbe.org/2a59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a59 RCSB], [https://www.ebi.ac.uk/pdbsum/2a59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a59 ProSAT]</span></td></tr>
[[2a59]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A59 OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/RIB4_SCHPO RIB4_SCHPO] Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. Also binds riboflavin with an unexpected high affinity.<ref>PMID:11856310</ref>
<ref group="xtra">PMID:015265040</ref><ref group="xtra">PMID:016516230</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Category: Riboflavin synthase]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Schizosaccharomyces pombe]]
Check<jmol>
[[Category: Bacher, A.]]
  <jmolCheckbox>
[[Category: Breithaupt, C.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a5/2a59_consurf.spt"</scriptWhenChecked>
[[Category: Cushman, M.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Fischer, M.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Gerhardt, S.]]
  </jmolCheckbox>
[[Category: Haase, I.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a59 ConSurf].
[[Category: Huber, R.]]
<div style="clear:both"></div>
[[Category: Koch, M.]]
== References ==
[[Category: Weber, S.]]
<references/>
[[Category: 5-nitroso-6-ribitylamino-2]]
__TOC__
[[Category: 7-dimethyl-8-ribityllumazine synthase]]
</StructureSection>
[[Category: Lusy]]
[[Category: Large Structures]]
[[Category: Mutant w27y]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Transferase]]
[[Category: Bacher A]]
[[Category: Breithaupt C]]
[[Category: Cushman M]]
[[Category: Fischer M]]
[[Category: Gerhardt S]]
[[Category: Haase I]]
[[Category: Huber R]]
[[Category: Koch M]]
[[Category: Weber S]]

Latest revision as of 12:11, 14 February 2024

Structure of 6,7-Dimethyl-8-ribityllumazine synthase from Schizosaccharomyces pombe mutant W27Y with bound ligand 5-nitroso-6-ribitylamino-2,4(1H,3H)-pyrimidinedioneStructure of 6,7-Dimethyl-8-ribityllumazine synthase from Schizosaccharomyces pombe mutant W27Y with bound ligand 5-nitroso-6-ribitylamino-2,4(1H,3H)-pyrimidinedione

Structural highlights

2a59 is a 5 chain structure with sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.7Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RIB4_SCHPO Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. Also binds riboflavin with an unexpected high affinity.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Fischer M, Haase I, Feicht R, Richter G, Gerhardt S, Changeux JP, Huber R, Bacher A. Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe. Eur J Biochem. 2002 Jan;269(2):519-26. PMID:11856310

2a59, resolution 2.70Å

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