2af0: Difference between revisions

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[[Image:2af0.png|left|200px]]


{{STRUCTURE_2af0| PDB=2af0 | SCENE= }}
==Structure of the Regulator of G-Protein Signaling Domain of RGS2==
<StructureSection load='2af0' size='340' side='right'caption='[[2af0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2af0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AF0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2af0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2af0 OCA], [https://pdbe.org/2af0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2af0 RCSB], [https://www.ebi.ac.uk/pdbsum/2af0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2af0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RGS2_HUMAN RGS2_HUMAN] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.<ref>PMID:11278586</ref> <ref>PMID:17901199</ref> <ref>PMID:7643615</ref> <ref>PMID:19736320</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/af/2af0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2af0 ConSurf].
<div style="clear:both"></div>


===Structure of the Regulator of G-Protein Signaling Domain of RGS2===
==See Also==
 
*[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]]
{{ABSTRACT_PUBMED_18434541}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[2af0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AF0 OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:018434541</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C.]]
[[Category: Large Structures]]
[[Category: Delft, F Von.]]
[[Category: Arrowsmith C]]
[[Category: Doyle, D A.]]
[[Category: Doyle DA]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Elkins, J M.]]
[[Category: Elkins JM]]
[[Category: Johannson, C.]]
[[Category: Johannson C]]
[[Category: Papagrigoriou, E.]]
[[Category: Papagrigoriou E]]
[[Category: Phillips, C.]]
[[Category: Phillips C]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Smee C]]
[[Category: Smee, C.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Von Delft F]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Helix]]
[[Category: Sgc]]
[[Category: Signaling protein]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]

Latest revision as of 16:40, 13 March 2024

Structure of the Regulator of G-Protein Signaling Domain of RGS2Structure of the Regulator of G-Protein Signaling Domain of RGS2

Structural highlights

2af0 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RGS2_HUMAN Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.[1] [2] [3] [4]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Heximer SP, Lim H, Bernard JL, Blumer KJ. Mechanisms governing subcellular localization and function of human RGS2. J Biol Chem. 2001 Apr 27;276(17):14195-203. Epub 2001 Jan 30. PMID:11278586 doi:10.1074/jbc.M009942200
  2. ↑ Gu S, Anton A, Salim S, Blumer KJ, Dessauer CW, Heximer SP. Alternative translation initiation of human regulators of G-protein signaling-2 yields a set of functionally distinct proteins. Mol Pharmacol. 2008 Jan;73(1):1-11. Epub 2007 Sep 27. PMID:17901199 doi:10.1124/mol.107.036285
  3. ↑ Wu HK, Heng HH, Shi XM, Forsdyke DR, Tsui LC, Mak TW, Minden MD, Siderovski DP. Differential expression of a basic helix-loop-helix phosphoprotein gene, G0S8, in acute leukemia and localization to human chromosome 1q31. Leukemia. 1995 Aug;9(8):1291-8. PMID:7643615
  4. ↑ Nguyen CH, Ming H, Zhao P, Hugendubler L, Gros R, Kimball SR, Chidiac P. Translational control by RGS2. J Cell Biol. 2009 Sep 7;186(5):755-65. PMID:19736320 doi:jcb.200811058

2af0, resolution 2.30Å

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