2a3d: Difference between revisions

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-[[Image:2a3d.png|left|200px]]
-{{STRUCTURE_2a3d|  PDB=2a3d  |  SCENE=  }}
+==SOLUTION STRUCTURE OF A DE NOVO DESIGNED SINGLE CHAIN THREE-HELIX BUNDLE (A3D)==
+<StructureSection load='2a3d' size='340' side='right'caption='[[2a3d]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2a3d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. The October 2005 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Designer Proteins''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2005_10 10.2210/rcsb_pdb/mom_2005_10]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A3D FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a3d OCA], [https://pdbe.org/2a3d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a3d RCSB], [https://www.ebi.ac.uk/pdbsum/2a3d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a3d ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Although de novo protein design is an important endeavor with implications for understanding protein folding, until now, structures have been determined for only a few 25- to 30-residue designed miniproteins. Here, the NMR solution structure of a complex 73-residue three-helix bundle protein, alpha3D, is reported. The structure of alpha3D was not based on any natural protein, and yet it shows thermodynamic and spectroscopic properties typical of native proteins. A variety of features contribute to its unique structure, including electrostatics, the packing of a diverse set of hydrophobic side chains, and a loop that incorporates common capping motifs. Thus, it is now possible to design a complex protein with a well defined and predictable three-dimensional structure.
-===SOLUTION STRUCTURE OF A DE NOVO DESIGNED SINGLE CHAIN THREE-HELIX BUNDLE (A3D)===
+Solution structure and dynamics of a de novo designed three-helix bundle protein.,Walsh ST, Cheng H, Bryson JW, Roder H, DeGrado WF Proc Natl Acad Sci U S A. 1999 May 11;96(10):5486-91. PMID:10318910<ref>PMID:10318910</ref>
-{{ABSTRACT_PUBMED_10318910}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 2a3d" style="background-color:#fffaf0;"></div>
-[[2a3d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. The October 2005 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Designer Proteins''  by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2005_10 10.2210/rcsb_pdb/mom_2005_10]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3D OCA].
+== References ==
+<references/>
-==Reference==
+__TOC__
-<ref group="xtra">PMID:010318910</ref><references group="xtra"/>
+</StructureSection>
 [[Category: Designer Proteins]]
+[[Category: Large Structures]]
 [[Category: RCSB PDB Molecule of the Month]]
 [[Category: Synthetic construct]]
-[[Category: Bryson, J W.]]
+[[Category: Bryson JW]]
-[[Category: Cheng, H.]]
+[[Category: Cheng H]]
-[[Category: Degrado, W F.]]
+[[Category: Degrado WF]]
-[[Category: Roder, H.]]
+[[Category: Roder H]]
-[[Category: Walsh, S T.R.]]
+[[Category: Walsh STR]]
-[[Category: Three-helix bundle]]