2afw: Difference between revisions

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-[[Image:2afw.png|left|200px]]
-{{STRUCTURE_2afw|  PDB=2afw  |  SCENE=  }}
+==Crystal structure of human glutaminyl cyclase in complex with N-acetylhistamine==
+<StructureSection load='2afw' size='340' side='right'caption='[[2afw]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2afw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AFW FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AHN:N-[2-(1H-IMIDAZOL-4-YL)ETHYL]ACETAMIDE'>AHN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2afw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2afw OCA], [https://pdbe.org/2afw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2afw RCSB], [https://www.ebi.ac.uk/pdbsum/2afw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2afw ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/QPCT_HUMAN QPCT_HUMAN] Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.<ref>PMID:15063747</ref> <ref>PMID:18486145</ref> <ref>PMID:21288892</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/af/2afw_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2afw ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of human glutaminyl cyclase in complex with N-acetylhistamine===
+==See Also==
+*[[Glutaminyl cyclase|Glutaminyl cyclase]]
-{{ABSTRACT_PUBMED_16135565}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[2afw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AFW OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:016135565</ref><references group="xtra"/>
-[[Category: Glutaminyl-peptide cyclotransferase]]
 [[Category: Homo sapiens]]
-[[Category: Cheng, W J.]]
+[[Category: Large Structures]]
-[[Category: Huang, K F.]]
+[[Category: Cheng WJ]]
-[[Category: Ko, T P.]]
+[[Category: Huang KF]]
-[[Category: Liu, Y L.]]
+[[Category: Ko TP]]
-[[Category: Wang, A H.J.]]
+[[Category: Liu YL]]
-[[Category: Alpha-beta protein]]
+[[Category: Wang AHJ]]
-[[Category: Metalloprotein]]
-[[Category: Transferase]]