1z0f: Difference between revisions

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-[[Image:1z0f.png|left|200px]]
-{{STRUCTURE_1z0f|  PDB=1z0f  |  SCENE=  }}
+==GDP-Bound Rab14 GTPase==
+<StructureSection load='1z0f' size='340' side='right'caption='[[1z0f]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1z0f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z0F FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z0f OCA], [https://pdbe.org/1z0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z0f RCSB], [https://www.ebi.ac.uk/pdbsum/1z0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z0f ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RAB14_HUMAN RAB14_HUMAN] Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.<ref>PMID:22595670</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z0/1z0f_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z0f ConSurf].
+<div style="clear:both"></div>
-===GDP-Bound Rab14 GTPase===
+==See Also==
+*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
-{{ABSTRACT_PUBMED_16034420}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[1z0f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z0F OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:016034420</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Eathiraj, S.]]
+[[Category: Large Structures]]
-[[Category: Lambright, D G.]]
+[[Category: Eathiraj S]]
-[[Category: Pan, X.]]
+[[Category: Lambright DG]]
-[[Category: Ritacco, C.]]
+[[Category: Pan X]]
-[[Category: Protein transport]]
+[[Category: Ritacco C]]
-[[Category: Rab gtpase]]
-[[Category: Rab14]]
-[[Category: Vesicular trafficking]]