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==Structure of 5'-deoxy-5'-methylthioadenosine phosphorylase homologue from Sulfolobus tokodaii== | |||
<StructureSection load='1v4n' size='340' side='right'caption='[[1v4n]], [[Resolution|resolution]] 2.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1v4n]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurisphaera_tokodaii Sulfurisphaera tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V4N FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v4n OCA], [https://pdbe.org/1v4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v4n RCSB], [https://www.ebi.ac.uk/pdbsum/1v4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v4n ProSAT]</span></td></tr> | ||
[[1v4n]] is a 3 chain structure with sequence from [ | </table> | ||
[[ | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/F9VN03_SULTO F9VN03_SULTO] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.[HAMAP-Rule:MF_01963] | ||
[[Category: Kawarabayasi | == Evolutionary Conservation == | ||
[[Category: Kitago | [[Image:Consurf_key_small.gif|200px|right]] | ||
[[Category: Sakai | Check<jmol> | ||
[[Category: Tanaka | <jmolCheckbox> | ||
[[Category: Tsujimura | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v4/1v4n_consurf.spt"</scriptWhenChecked> | ||
[[Category: Watanabe | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
[[Category: Yao | <text>to colour the structure by Evolutionary Conservation</text> | ||
[[Category: Yasutake | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v4n ConSurf]. | |||
<div style="clear:both"></div> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Sulfurisphaera tokodaii]] | |||
[[Category: Kawarabayasi Y]] | |||
[[Category: Kitago Y]] | |||
[[Category: Sakai N]] | |||
[[Category: Tanaka I]] | |||
[[Category: Tsujimura M]] | |||
[[Category: Watanabe N]] | |||
[[Category: Yao M]] | |||
[[Category: Yasutake Y]] | |||
Latest revision as of 03:35, 21 November 2024
Structure of 5'-deoxy-5'-methylthioadenosine phosphorylase homologue from Sulfolobus tokodaiiStructure of 5'-deoxy-5'-methylthioadenosine phosphorylase homologue from Sulfolobus tokodaii
Structural highlights
FunctionF9VN03_SULTO Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.[HAMAP-Rule:MF_01963] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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