1u5d: Difference between revisions

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-[[Image:1u5d.png|left|200px]]
-{{STRUCTURE_1u5d|  PDB=1u5d  |  SCENE=  }}
+==Crystal Structure of the PH domain of SKAP55==
+<StructureSection load='1u5d' size='340' side='right'caption='[[1u5d]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-===Crystal Structure of the PH domain of SKAP55===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1u5d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U5D FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[1u5d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5D OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5d OCA], [https://pdbe.org/1u5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u5d RCSB], [https://www.ebi.ac.uk/pdbsum/1u5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5d ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SKAP1_HUMAN SKAP1_HUMAN] Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.<ref>PMID:10856234</ref> <ref>PMID:11909961</ref> <ref>PMID:12652296</ref> <ref>PMID:15939789</ref> <ref>PMID:16980616</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u5/1u5d_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u5d ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Eck, M J.]]
+[[Category: Large Structures]]
-[[Category: Neel, B G.]]
+[[Category: Eck MJ]]
-[[Category: Swanson, K D.]]
+[[Category: Neel BG]]
-[[Category: Tang, Y.]]
+[[Category: Swanson KD]]
-[[Category: Ph domain]]
+[[Category: Tang Y]]
-[[Category: Signaling protein]]