1xe3: Difference between revisions

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-[[Image:1xe3.png|left|200px]]
-{{STRUCTURE_1xe3|  PDB=1xe3  |  SCENE=  }}
+==Crystal Structure of purine nucleoside phosphorylase DeoD from Bacillus anthracis==
+<StructureSection load='1xe3' size='340' side='right'caption='[[1xe3]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1xe3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XE3 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.24&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xe3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xe3 OCA], [https://pdbe.org/1xe3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xe3 RCSB], [https://www.ebi.ac.uk/pdbsum/1xe3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xe3 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DEOD_BACAN DEOD_BACAN]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/1xe3_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xe3 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Protein structures from the causative agent of anthrax (Bacillus anthracis) are being determined as part of a structural genomics programme. Amongst initial candidates for crystallographic analysis are enzymes involved in nucleotide biosynthesis, since these are recognized as potential targets in antibacterial therapy. Purine nucleoside phosphorylase is a key enzyme in the purine-salvage pathway. The crystal structure of purine nucleoside phosphorylase (DeoD) from B. anthracis has been solved by molecular replacement at 2.24 A resolution and refined to an R factor of 18.4%. This is the first report of a DeoD structure from a Gram-positive bacterium.
-===Crystal Structure of purine nucleoside phosphorylase DeoD from Bacillus anthracis===
+Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis.,Grenha R, Levdikov VM, Fogg MJ, Blagova EV, Brannigan JA, Wilkinson AJ, Wilson KS Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 May 1;61(Pt, 5):459-62. Epub 2005 Apr 9. PMID:16511068<ref>PMID:16511068</ref>
-{{ABSTRACT_PUBMED_16511068}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1xe3" style="background-color:#fffaf0;"></div>
-==About this Structure==
+==See Also==
-[[1xe3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XE3 OCA].
+*[[Purine nucleoside phosphorylase 3D structures|Purine nucleoside phosphorylase 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:016511068</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Bacillus anthracis]]
-[[Category: Purine-nucleoside phosphorylase]]
+[[Category: Large Structures]]
-[[Category: Blagova, E V.]]
+[[Category: Blagova EV]]
-[[Category: Brannigan, J A.]]
+[[Category: Brannigan JA]]
-[[Category: Fogg, M.]]
+[[Category: Fogg M]]
-[[Category: Grenha, R.]]
+[[Category: Grenha R]]
-[[Category: Levdikov, V M.]]
+[[Category: Levdikov VM]]
-[[Category: SPINE, Structural Proteomics in Europe.]]
+[[Category: Wilkinson AJ]]
-[[Category: Wilkinson, A J.]]
+[[Category: Wilson KS]]
-[[Category: Wilson, K S.]]
-[[Category: Deod]]
-[[Category: Purine nucleoside phosphorylase]]
-[[Category: Spine]]
-[[Category: Structural genomic]]
-[[Category: Structural proteomics in europe]]
-[[Category: Transferase]]