1sv4: Difference between revisions

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-[[Image:1sv4.png|left|200px]]
-{{STRUCTURE_1sv4|  PDB=1sv4  |  SCENE=  }}
+==Crystal Structure of Yan-SAM==
+<StructureSection load='1sv4' size='340' side='right'caption='[[1sv4]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1sv4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SV4 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sv4 OCA], [https://pdbe.org/1sv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sv4 RCSB], [https://www.ebi.ac.uk/pdbsum/1sv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sv4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/POK_DROME POK_DROME] Negative regulator of photoreceptor development that acts antagonistically to the proneural signal mediated by RAS. It acts upstream of SINA to inhibit R7 development.<ref>PMID:1505027</ref> <ref>PMID:1495974</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sv/1sv4_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sv4 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Yan, an ETS family transcriptional repressor, is regulated by receptor tyrosine kinase signaling via the Ras/MAPK pathway. Phosphorylation and downregulation of Yan is facilitated by a protein called Mae. Yan and Mae interact through their SAM domains. We find that repression by Yan requires the formation of a higher order structure mediated by Yan-SAM polymerization. Moreover, a crystal structure of the Yan-SAM/Mae-SAM complex shows that Mae-SAM specifically recognizes a surface on Yan-SAM that is also required for Yan-SAM polymerization. Mae-SAM binds to Yan-SAM with approximately 1000-fold higher affinity than Yan-SAM binds to itself and can effectively depolymerize Yan-SAM. Mutations on Mae that specifically disrupt its SAM domain-dependent interactions with Yan disable the derepression function of Mae in vivo. Depolymerization of Yan by Mae represents a novel mechanism of transcriptional control that sensitizes Yan for regulation by receptor tyrosine kinases.
-===Crystal Structure of Yan-SAM===
+Derepression by depolymerization; structural insights into the regulation of Yan by Mae.,Qiao F, Song H, Kim CA, Sawaya MR, Hunter JB, Gingery M, Rebay I, Courey AJ, Bowie JU Cell. 2004 Jul 23;118(2):163-73. PMID:15260987<ref>PMID:15260987</ref>
-{{ABSTRACT_PUBMED_15260987}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 1sv4" style="background-color:#fffaf0;"></div>
-[[1sv4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SV4 OCA].
+== References ==
+<references/>
-==Reference==
+__TOC__
-<ref group="xtra">PMID:015260987</ref><references group="xtra"/>
+</StructureSection>
 [[Category: Drosophila melanogaster]]
-[[Category: Bowie, J U.]]
+[[Category: Large Structures]]
-[[Category: Courey, A J.]]
+[[Category: Bowie JU]]
-[[Category: Gingery, M.]]
+[[Category: Courey AJ]]
-[[Category: Hunter, J B.]]
+[[Category: Gingery M]]
-[[Category: Kim, C A.]]
+[[Category: Hunter JB]]
-[[Category: Qiao, F.]]
+[[Category: Kim CA]]
-[[Category: Rebay, I.]]
+[[Category: Qiao F]]
-[[Category: Sawaya, M R.]]
+[[Category: Rebay I]]
-[[Category: Song, H.]]
+[[Category: Sawaya MR]]
-[[Category: Alpha-helix]]
+[[Category: Song H]]
-[[Category: Transcription]]