1rfh: Difference between revisions

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-[[Image:1rfh.png|left|200px]]
-{{STRUCTURE_1rfh|  PDB=1rfh  |  SCENE=  }}
+==Solution structure of the C1 domain of Nore1, a novel Ras effector==
+<StructureSection load='1rfh' size='340' side='right'caption='[[1rfh]]' scene=''>
-===Solution structure of the C1 domain of Nore1, a novel Ras effector===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1rfh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RFH FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[1rfh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RFH OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rfh OCA], [https://pdbe.org/1rfh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rfh RCSB], [https://www.ebi.ac.uk/pdbsum/1rfh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rfh ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RASF5_MOUSE RASF5_MOUSE] Potental tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis.<ref>PMID:11864565</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rf/1rfh_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rfh ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Bayer, P.]]
+[[Category: Bayer P]]
-[[Category: Guiberman, E.]]
+[[Category: Guiberman E]]
-[[Category: Harjes, S.]]
+[[Category: Harjes S]]
-[[Category: Herrmann, C.]]
+[[Category: Herrmann C]]
-[[Category: Mueller, K H.]]
+[[Category: Mueller KH]]
-[[Category: Wohlgemuth, S.]]
+[[Category: Wohlgemuth S]]
-[[Category: Apoptosis]]
-[[Category: Cysteine rich domain]]
-[[Category: Metal binding protein]]
-[[Category: Signal transduction]]