1r8b: Difference between revisions

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[[Image:1r8b.png|left|200px]]


{{STRUCTURE_1r8b| PDB=1r8b | SCENE= }}
==Crystal Structures of an Archaeal Class I CCA-Adding Enzyme and Its Nucleotide==
<StructureSection load='1r8b' size='340' side='right'caption='[[1r8b]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1r8b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R8B FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r8b OCA], [https://pdbe.org/1r8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r8b RCSB], [https://www.ebi.ac.uk/pdbsum/1r8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r8b ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CCA_ARCFU CCA_ARCFU] Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.<ref>PMID:14592988</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r8/1r8b_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r8b ConSurf].
<div style="clear:both"></div>


===Crystal Structures of an Archaeal Class I CCA-Adding Enzyme and Its Nucleotide===
==See Also==
 
*[[CCA-adding enzyme 3D structures|CCA-adding enzyme 3D structures]]
{{ABSTRACT_PUBMED_14636575}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[1r8b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R8B OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:014636575</ref><references group="xtra"/>
[[Category: Archaeoglobus fulgidus]]
[[Category: Archaeoglobus fulgidus]]
[[Category: TRNA adenylyltransferase]]
[[Category: Large Structures]]
[[Category: Li, F.]]
[[Category: Li F]]
[[Category: Steitz, T A.]]
[[Category: Steitz TA]]
[[Category: Wang, J.]]
[[Category: Wang J]]
[[Category: Weiner, A M.]]
[[Category: Weiner AM]]
[[Category: Xiong, Y.]]
[[Category: Xiong Y]]
[[Category: Cca adding enzyme]]
[[Category: Incoming nucleotide]]
[[Category: Nucleotidyltransferase]]
[[Category: Transferase]]

Latest revision as of 11:21, 14 February 2024

Crystal Structures of an Archaeal Class I CCA-Adding Enzyme and Its NucleotideCrystal Structures of an Archaeal Class I CCA-Adding Enzyme and Its Nucleotide

Structural highlights

1r8b is a 1 chain structure with sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CCA_ARCFU Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Okabe M, Tomita K, Ishitani R, Ishii R, Takeuchi N, Arisaka F, Nureki O, Yokoyama S. Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure. EMBO J. 2003 Nov 3;22(21):5918-27. PMID:14592988 doi:http://dx.doi.org/10.1093/emboj/cdg563

1r8b, resolution 2.00Å

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