1ri4: Difference between revisions

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[[Image:1ri4.png|left|200px]]


{{STRUCTURE_1ri4|  PDB=1ri4  |  SCENE=  }}
==Structure and mechanism of mRNA cap (guanine N-7) methyltransferase==
 
<StructureSection load='1ri4' size='340' side='right'caption='[[1ri4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
===Structure and mechanism of mRNA cap (guanine N-7) methyltransferase===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1ri4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Encephalitozoon_cuniculi Encephalitozoon cuniculi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RI4 FirstGlance]. <br>
{{ABSTRACT_PUBMED_14731396}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ri4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ri4 OCA], [https://pdbe.org/1ri4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ri4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ri4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ri4 ProSAT]</span></td></tr>
[[1ri4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Encephalitozoon_cuniculi Encephalitozoon cuniculi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RI4 OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/MCES_ENCCU MCES_ENCCU] mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.<ref>PMID:15760890</ref>  
<ref group="xtra">PMID:014731396</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ri/1ri4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ri4 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Encephalitozoon cuniculi]]
[[Category: Encephalitozoon cuniculi]]
[[Category: Fabrega, C.]]
[[Category: Large Structures]]
[[Category: Hausmann, S.]]
[[Category: Fabrega C]]
[[Category: Lima, C D.]]
[[Category: Hausmann S]]
[[Category: Shen, V.]]
[[Category: Lima CD]]
[[Category: Shuman, S.]]
[[Category: Shen V]]
[[Category: Cap]]
[[Category: Shuman S]]
[[Category: M7g]]
[[Category: Messenger rna cap]]
[[Category: Methyltransferase]]
[[Category: Rna]]
[[Category: Transferase]]

Latest revision as of 11:23, 14 February 2024

Structure and mechanism of mRNA cap (guanine N-7) methyltransferaseStructure and mechanism of mRNA cap (guanine N-7) methyltransferase

Structural highlights

1ri4 is a 1 chain structure with sequence from Encephalitozoon cuniculi. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MCES_ENCCU mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Hausmann S, Zheng S, Fabrega C, Schneller SW, Lima CD, Shuman S. Encephalitozoon cuniculi mRNA cap (guanine N-7) methyltransferase: methyl acceptor specificity, inhibition BY S-adenosylmethionine analogs, and structure-guided mutational analysis. J Biol Chem. 2005 May 27;280(21):20404-12. Epub 2005 Mar 9. PMID:15760890 doi:10.1074/jbc.M501073200

1ri4, resolution 2.40Å

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