Porphobilinogen synthase: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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+<StructureSection load='' size='450' side='right' caption='Yeast porphobilinogen synthase complex with  laevulunic acid and Zn+2 ion (grey)  (PDB entry [[1h7n]])' scene='52/526179/Cv/1'>
-'''Porphobilinogen synthase''' (PBS) catalyzes the formation of porphobilinogen (PBG) from 2 molecules of aminolevulinic acid (ALA).  PBS participates in porphyrin biosynthesis.  Levulinic acid (LA) is an inhibitor of PBS.  Porphyrin is the precursor of hemes, chlorophyll and vitamin B12.  PBS deficiency can be caused by lead and other heavy metal poisoning.
+== Function ==
+'''Porphobilinogen synthase''' or '''δ-aminolaevulinic acid dehydratase''' (PBS) catalyzes the formation of porphobilinogen (PBG) from 2 molecules of aminolaevulinic acid (ALA).  PBS participates in porphyrin biosynthesis<ref>PMID:15381398</ref>.  Levulinic acid (LA) is an inhibitor of PBS.  Porphyrin is the precursor of hemes, chlorophyll and vitamin B12.
-===3D structures of porphobilinogen synthase===
+== Disease ==
+PBS deficiency can be caused by lead and other heavy metal poisoning<ref>PMID:7104498</ref>.
-[[1aw5]] – yPBS (mutant)  + Zn – yeast<br />
+== Structural highlights ==
-[[1qml]] - yPBS + Hg<br />
+The biological assembly of Yeast porphobilinogen synthase is <scene name='52/526179/Cv/4'>homooctamer</scene>. The <scene name='52/526179/Cv/5'>active site of PBS contains the substrate laevulinic acid and Zn+2 ion</scene><ref>PMID:11545591</ref>. Water molecules are shown as red spheres.
-[[1qnv]] - yPBS + Pb<br />
-[[1pv8 – hPBS (mutant) – human<br />
-[[2z0i]], [[2z1b]] - PBS - mouse<br />
-[[1w54]], [[1w56]], [[1w5m]], [[1w5n]], [[1w5o]], [[1w5p]], [[1w5q]] - PaPBS (mutant) + Mg + Zn – ''Pseudomonas aeruginosa''
-==Porphobilinogen synthase complex==
+</StructureSection>
-[[1b4k]] - PaPBS + LA + Zn<br />
+==3D structures of porphobilinogen synthase==
-[[1b4e]] - EcPBS + LA + Zn – ''Escherichia coli''<br />
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[1ylv]], [[1h7n]] - yPBS + LA + Zn<br />
+{{#tree:id=OrganizedByTopic|openlevels=0|
-[[1w31]] - yPBS + LA derivative + Zn<br />
-[[1h7o]] - yPBS + ALA + Zn<br />
+*Porphobilinogen synthase
-[[1h7r]], [[1h7p]], [[1eb3]], [[1gjp]] - yPBS + inhibitor + Zn<br />
-[[1ohl]] - yPBS + intermediate + Zn<br />
+**[[5hms]], [[5hnr]] – hPBS + Zn – human<br />
-[[1i8j]], [[1l6s]], [[1l6y]] - EcPBS + inhibitor + Mg + Zn<br />
+**[[1pv8]] – hPBS (mutant)<br />
-[[2c1h]] - PBS + inhibitor + Mg – ''Chlorobium vibrioforme'' <br />
+**[[2z0i]], [[2z1b]] - PBS - mouse<br />
-[[2c13]], [[2c14]] - PaPBS (mutant) + inhibitor + Mg<br />
+**[[1aw5]] – yPBS (mutant)  + Zn – yeast<br />
-[[2c15]], [[2c16]], [[2c18]], [[2c19]] - PaPBS + inhibitor + Mg<br />
+**[[1qml]] - yPBS + Hg<br />
-[[1e51]] - hPBS + PBG + Zn<br />
+**[[1qnv]] - yPBS + Pb<br />
-[[1gzg]] - PaPBS + LA derivative + Mg<br />
+**[[1w54]], [[1w56]], [[1w5m]], [[1w5n]], [[1w5o]], [[1w5p]], [[1w5q]] - PaPBS (mutant) + Mg + Zn – ''Pseudomonas aeruginosa''<br />
-[[2woq]] - PaPBS + antibiotic + Mg<br />
+**[[5lzl]] - PBS + Zn – ''Pyrobaculum calidifontis''<br />
-[[1w1z]] - PBS + LA + Mg – ''Prosthecochloris vibrioformis''
+*Porphobilinogen synthase complex
+**[[1e51]] - hPBS + PBG + Zn<br />
+**[[1ylv]], [[1h7n]] - yPBS + LA + Zn<br />
+**[[1w31]] - yPBS + LA derivative + Zn<br />
+**[[1h7o]] - yPBS + ALA + Zn<br />
+**[[1h7r]], [[1h7p]], [[1eb3]], [[1gjp]] - yPBS + inhibitor + Zn<br />
+**[[1ohl]] - yPBS + intermediate + Zn<br />
+**[[1b4e]] - EcPBS + LA + Zn – ''Escherichia coli''<br />
+**[[5mhb]] - EcPBS + PBG + Zn<br />
+**[[1i8j]], [[1l6s]], [[1l6y]] - EcPBS + inhibitor + Mg + Zn<br />
+**[[2c1h]] - PBS + inhibitor + Mg – ''Chlorobium vibrioforme'' <br />
+**[[2c13]], [[2c14]] - PaPBS (mutant) + inhibitor + Mg<br />
+**[[2c15]], [[2c16]], [[2c18]], [[2c19]] - PaPBS + inhibitor + Mg<br />
+**[[1b4k]] - PaPBS + LA + Zn<br />
+**[[1gzg]] - PaPBS + LA derivative + Mg<br />
+**[[2woq]] - PaPBS + antibiotic + Mg<br />
+**[[1w1z]] - PBS + LA + Mg – ''Prosthecochloris vibrioformis''<br />
+**[[3obk]] - PBS residues 303-658 + Mg + PBG – ''Toxoplasma gondii''<br />
+}}
+== References ==
+<references/>
+[[Category:Topic Page]]