1tdt: Difference between revisions

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-[[Image:1tdt.gif|left|200px]]<br /><applet load="1tdt" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="1tdt, resolution 2.2&Aring;" />
-'''THREE-DIMENSIONAL STRUCTURE OF TETRAHYDRODIPICOLINATE-N-SUCCINLYTRANSFERASE'''<br />
-==Overview==
+==THREE-DIMENSIONAL STRUCTURE OF TETRAHYDRODIPICOLINATE-N-SUCCINYLTRANSFERASE==
-The conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA is catalyzed by tetrahydrodipicolinate N-succinyltransferase and is the committed step in the succinylase pathway by which bacteria synthesize L-lysine and meso-diaminopimelate, a component of peptidoglycan. The X-ray crystal structure of THDP succinyltransferase has been determined to 2.2 A resolution and has been refined to a crystallographic R-factor of 17.0%. The enzyme is trimeric and displays the left-handed parallel beta-helix (L beta H) structural motif encoded by the "hexapeptide repeat" amino acid sequence motif [Raetz, C.R.H., &amp; Roderick, S.L. (1995) Science 270, 997-1000]. The approximate location of the active site of THDP succinyltransferase is suggested by the proximity of binding sites for two inhibitors: p-(chloromercuri)benzenesulfonic acid and cobalt ion, both of which bind to the L beta H domain.
+<StructureSection load='1tdt' size='340' side='right'caption='[[1tdt]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[1tdt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_variant_bovis Mycobacterium tuberculosis variant bovis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TDT FirstGlance]. <br>
-TDT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_bovis Mycobacterium bovis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TDT OCA].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tdt OCA], [https://pdbe.org/1tdt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tdt RCSB], [https://www.ebi.ac.uk/pdbsum/1tdt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tdt ProSAT]</span></td></tr>
-==Reference==
+</table>
-Three-dimensional structure of tetrahydrodipicolinate N-succinyltransferase., Beaman TW, Binder DA, Blanchard JS, Roderick SL, Biochemistry. 1997 Jan 21;36(3):489-94. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9012664 9012664]
+== Function ==
-[[Category: Mycobacterium bovis]]
+[https://www.uniprot.org/uniprot/DAPD_UNKP DAPD_UNKP]
-[[Category: Single protein]]
+== Evolutionary Conservation ==
-[[Category: Beaman, T W.]]
+[[Image:Consurf_key_small.gif|200px|right]]
-[[Category: Binder, D W.]]
+Check<jmol>
-[[Category: Blanchard, J S.]]
+  <jmolCheckbox>
-[[Category: Roderick, S L.]]
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/td/1tdt_consurf.spt"</scriptWhenChecked>
-[[Category: cell wall biosynthesis]]
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-[[Category: hexapeptide transferase]]
+    <text>to colour the structure by Evolutionary Conservation</text>
-[[Category: lysine metabolism]]
+  </jmolCheckbox>
-[[Category: succinyltransferase]]
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tdt ConSurf].
-[[Category: transferase]]
+<div style="clear:both"></div>
+__TOC__
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:12:33 2008''
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mycobacterium tuberculosis variant bovis]]
+[[Category: Beaman TW]]
+[[Category: Binder DW]]
+[[Category: Blanchard JS]]
+[[Category: Roderick SL]]