1sv9: Difference between revisions

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-[[Image:1sv9.gif|left|200px]]<br /><applet load="1sv9" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="1sv9, resolution 2.71&Aring;" />
-'''Crystal structure of the complex formed between groupII phospholipase A2 and anti-inflammatory agent 2-[(2,6-Dichlorophenyl)amino] benzeneacetic acid at 2.7A resolution'''<br />
-==About this Structure==
+==Crystal structure of the complex formed between groupII phospholipase A2 and anti-inflammatory agent 2-[(2,6-Dichlorophenyl)amino] benzeneacetic acid at 2.7A resolution==
-SV9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Daboia_russellii_russellii Daboia russellii russellii] with <scene name='pdbligand=DIF:'>DIF</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SV9 OCA].
+<StructureSection load='1sv9' size='340' side='right'caption='[[1sv9]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
-[[Category: Daboia russellii russellii]]
+== Structural highlights ==
-[[Category: Phospholipase A(2)]]
+<table><tr><td colspan='2'>[[1sv9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_russelii_russelii Daboia russelii russelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SV9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SV9 FirstGlance]. <br>
-[[Category: Single protein]]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.71&#8491;</td></tr>
-[[Category: Ethayathulla, A S.]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DIF:2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC+ACID'>DIF</scene></td></tr>
-[[Category: Sharma, S.]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sv9 OCA], [https://pdbe.org/1sv9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sv9 RCSB], [https://www.ebi.ac.uk/pdbsum/1sv9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sv9 ProSAT]</span></td></tr>
-[[Category: Singh, N.]]
+</table>
-[[Category: Singh, T P.]]
+== Function ==
-[[Category: kumar, R Prem.]]
+[https://www.uniprot.org/uniprot/PA2B8_DABRR PA2B8_DABRR] Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:2115497</ref> <ref>PMID:8835338</ref>
-[[Category: kumar, R Senthil.]]
+== Evolutionary Conservation ==
-[[Category: DIF]]
+[[Image:Consurf_key_small.gif|200px|right]]
-[[Category: 2 7a resolution]]
+Check<jmol>
-[[Category: complex]]
+  <jmolCheckbox>
-[[Category: crystal structure]]
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sv/1sv9_consurf.spt"</scriptWhenChecked>
-[[Category: diclofenac]]
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-[[Category: phospholipase a2]]
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sv9 ConSurf].
+<div style="clear:both"></div>
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:05:31 2008''
+==See Also==
+*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Daboia russelii russelii]]
+[[Category: Large Structures]]
+[[Category: Ethayathulla AS]]
+[[Category: Prem kumar R]]
+[[Category: Senthil kumar R]]
+[[Category: Sharma S]]
+[[Category: Singh N]]
+[[Category: Singh TP]]