1pmr: Difference between revisions

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[[Image:1pmr.png|left|200px]]


{{STRUCTURE_1pmr| PDB=1pmr | SCENE= }}
==LIPOYL DOMAIN FROM THE DIHYDROLIPOYL SUCCINYLTRANSFERASE COMPONENT OF THE 2-OXOGLUTARATE DEHYDROGENASE MULTIENZYME COMPLEX OF ESCHERICHIA COLI, NMR, 25 STRUCTURES==
<StructureSection load='1pmr' size='340' side='right'caption='[[1pmr]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1pmr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The October 2012 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Citric Acid Cycle''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2012_10 10.2210/rcsb_pdb/mom_2012_10]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PMR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PMR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pmr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pmr OCA], [https://pdbe.org/1pmr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pmr RCSB], [https://www.ebi.ac.uk/pdbsum/1pmr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pmr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ODO2_ECOLI ODO2_ECOLI] The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pm/1pmr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pmr ConSurf].
<div style="clear:both"></div>


===LIPOYL DOMAIN FROM THE DIHYDROLIPOYL SUCCINYLTRANSFERASE COMPONENT OF THE 2-OXOGLUTARATE DEHYDROGENASE MULTIENZYME COMPLEX OF ESCHERICHIA COLI, NMR, 25 STRUCTURES===
==See Also==
 
*[[2-oxoglutarate dehydrogenase 3D structures|2-oxoglutarate dehydrogenase 3D structures]]
{{ABSTRACT_PUBMED_8950276}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Citric Acid Cycle]]
[[1pmr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PMR OCA].
 
==Reference==
<ref group="xtra">PMID:008950276</ref><references group="xtra"/>
[[Category: Dihydrolipoyllysine-residue succinyltransferase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Broadhurst, R W.]]
[[Category: Large Structures]]
[[Category: Howard, M J.]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Perham, R N.]]
[[Category: Broadhurst RW]]
[[Category: Ricaud, P M.]]
[[Category: Howard MJ]]
[[Category: Roberts, E L.]]
[[Category: Perham RN]]
[[Category: 2-oxoglutarate dehydrogenase]]
[[Category: Ricaud PM]]
[[Category: Complex]]
[[Category: Roberts EL]]
[[Category: Glycolysis]]
[[Category: Lipoyl domain]]
[[Category: Transferase]]

Latest revision as of 08:56, 17 April 2024

LIPOYL DOMAIN FROM THE DIHYDROLIPOYL SUCCINYLTRANSFERASE COMPONENT OF THE 2-OXOGLUTARATE DEHYDROGENASE MULTIENZYME COMPLEX OF ESCHERICHIA COLI, NMR, 25 STRUCTURESLIPOYL DOMAIN FROM THE DIHYDROLIPOYL SUCCINYLTRANSFERASE COMPONENT OF THE 2-OXOGLUTARATE DEHYDROGENASE MULTIENZYME COMPLEX OF ESCHERICHIA COLI, NMR, 25 STRUCTURES

Structural highlights

1pmr is a 1 chain structure with sequence from Escherichia coli. The October 2012 RCSB PDB Molecule of the Month feature on Citric Acid Cycle by David Goodsell is 10.2210/rcsb_pdb/mom_2012_10. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ODO2_ECOLI The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

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