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[[Image:1s1s.gif|left|200px]]<br /><applet load="1s1s" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1s1s, resolution 2.10&Aring;" />
'''Crystal Structure of ZipA in complex with indoloquinolizin 10b'''<br />


==Overview==
==Crystal Structure of ZipA in complex with indoloquinolizin 10b==
The binding of FtsZ to ZipA is a potential target for antibacterial therapy. Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key region of ZipA involved in FtsZ binding. The X-ray crystal structure of one of these molecules complexed with ZipA was solved. The structure revealed an unexpected binding mode, facilitated by desolvation of a loosely bound surface water.
<StructureSection load='1s1s' size='340' side='right'caption='[[1s1s]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1s1s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S1S FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WAC:N-{3-[(12BS)-7-OXO-1,3,4,6,7,12B-HEXAHYDROINDOLO[2,3-A]QUINOLIZIN-12(2H)-YL]PROPYL}PROPANE-2-SULFONAMIDE'>WAC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s1s OCA], [https://pdbe.org/1s1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s1s RCSB], [https://www.ebi.ac.uk/pdbsum/1s1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s1s ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ZIPA_ECOLI ZIPA_ECOLI] Interacts directly with the cell division protein FtsZ. Probable receptor for the septal ring structure, may anchor it to the inner-membrane.[HAMAP-Rule:MF_00509]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s1/1s1s_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s1s ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1S1S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=WAC:'>WAC</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1S OCA].
*[[Cell division protein 3D structures|Cell division protein 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction., Jennings LD, Foreman KW, Rush TS 3rd, Tsao DH, Mosyak L, Li Y, Sukhdeo MN, Ding W, Dushin EG, Kenny CH, Moghazeh SL, Petersen PJ, Ruzin AV, Tuckman M, Sutherland AG, Bioorg Med Chem Lett. 2004 Mar 22;14(6):1427-31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15006376 15006376]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Ding, W.]]
[[Category: Ding W]]
[[Category: Dushin, E G.]]
[[Category: Dushin EG]]
[[Category: Foreman, K W.]]
[[Category: Foreman KW]]
[[Category: III, T S.Rush.]]
[[Category: Jennings LD]]
[[Category: Jennings, L D.]]
[[Category: Kenny CH]]
[[Category: Kenny, C H.]]
[[Category: Li Y]]
[[Category: Li, Y.]]
[[Category: Moghazeh SL]]
[[Category: Moghazeh, S L.]]
[[Category: Mosyak L]]
[[Category: Mosyak, L.]]
[[Category: Petersen PJ]]
[[Category: Petersen, P J.]]
[[Category: Rush III TS]]
[[Category: Ruzin, A V.]]
[[Category: Ruzin AV]]
[[Category: Sukhdeo, M N.]]
[[Category: Sukhdeo MN]]
[[Category: Sutherland, A G.]]
[[Category: Sutherland AG]]
[[Category: Tsao, D H.]]
[[Category: Tsao DH]]
[[Category: Tuckman, M.]]
[[Category: Tuckman M]]
[[Category: WAC]]
[[Category: cell cycle]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:56:59 2008''

Latest revision as of 11:27, 14 February 2024

Crystal Structure of ZipA in complex with indoloquinolizin 10bCrystal Structure of ZipA in complex with indoloquinolizin 10b

Structural highlights

1s1s is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ZIPA_ECOLI Interacts directly with the cell division protein FtsZ. Probable receptor for the septal ring structure, may anchor it to the inner-membrane.[HAMAP-Rule:MF_00509]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1s1s, resolution 2.10Å

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