1nqw: Difference between revisions

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-[[Image:1nqw.png|left|200px]]
-{{STRUCTURE_1nqw|  PDB=1nqw  |  SCENE=  }}
+==Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 5-(6-D-ribitylamino-2,4(1H,3H)pyrimidinedione-5-yl)-1-pentyl-phosphonic acid==
+<StructureSection load='1nqw' size='340' side='right'caption='[[1nqw]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-===Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 5-(6-D-ribitylamino-2,4(1H,3H)pyrimidinedione-5-yl)-1-pentyl-phosphonic acid===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1nqw]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NQW FirstGlance]. <br>
-{{ABSTRACT_PUBMED_12684006}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5YL:5-(6-D-RIBITYLAMINO-2,4(1H,3H)PYRIMIDINEDIONE-5-YL)+PENTYL-1-PHOSPHONIC+ACID'>5YL</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqw OCA], [https://pdbe.org/1nqw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nqw RCSB], [https://www.ebi.ac.uk/pdbsum/1nqw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nqw ProSAT]</span></td></tr>
-[[1nqw]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQW OCA].
+</table>
+== Function ==
-==Reference==
+[https://www.uniprot.org/uniprot/RISB_AQUAE RISB_AQUAE] Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.<ref>PMID:12603336</ref> <ref>PMID:11237620</ref>
-<ref group="xtra">PMID:012684006</ref><references group="xtra"/>
+== Evolutionary Conservation ==
-[[Category: Aquifex aeolicus]]
+[[Image:Consurf_key_small.gif|200px|right]]
-[[Category: Riboflavin synthase]]
+Check<jmol>
-[[Category: Bacher, A.]]
+  <jmolCheckbox>
-[[Category: Cushman, M.]]
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nq/1nqw_consurf.spt"</scriptWhenChecked>
-[[Category: Fischer, M.]]
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-[[Category: Haase, I.]]
+    <text>to colour the structure by Evolutionary Conservation</text>
-[[Category: Ladenstein, R.]]
+  </jmolCheckbox>
-[[Category: Meining, W.]]
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nqw ConSurf].
-[[Category: Zhang, X.]]
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Aquifex aeolicus]]
-[[Category: Catalytic mechanism]]
+[[Category: Large Structures]]
-[[Category: Inhibitor complex]]
+[[Category: Bacher A]]
-[[Category: Lumazine synthase]]
+[[Category: Cushman M]]
-[[Category: Transferase]]
+[[Category: Fischer M]]
-[[Category: Vitamin biosynthesis]]
+[[Category: Haase I]]
+[[Category: Ladenstein R]]
+[[Category: Meining W]]
+[[Category: Zhang X]]