4b4c: Difference between revisions

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[[Image:4b4c.png|left|200px]]


{{STRUCTURE_4b4c| PDB=4b4c | SCENE= }}
==Crystal structure of the DNA-binding domain of human CHD1.==
<StructureSection load='4b4c' size='340' side='right'caption='[[4b4c]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4b4c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B4C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B4C FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b4c OCA], [https://pdbe.org/4b4c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b4c RCSB], [https://www.ebi.ac.uk/pdbsum/4b4c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b4c ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CHD1_HUMAN CHD1_HUMAN] ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.<ref>PMID:18042460</ref>


===Crystal structure of the DNA-binding domain of human CHD1.===
==See Also==
 
*[[Chromodomain-helicase-DNA-binding protein 3D structures|Chromodomain-helicase-DNA-binding protein 3D structures]]
 
*[[Helicase 3D structures|Helicase 3D structures]]
==About this Structure==
== References ==
[[4b4c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B4C OCA].
<references/>
[[Category: DNA helicase]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Allerston, C K.]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Allerston CK]]
[[Category: Bountra, C.]]
[[Category: Arrowsmith CH]]
[[Category: Burgess-Brown, N.]]
[[Category: Bountra C]]
[[Category: Carpenter, E P.]]
[[Category: Burgess-Brown N]]
[[Category: Cooper, C D.O.]]
[[Category: Carpenter EP]]
[[Category: Edwards, A.]]
[[Category: Cooper CDO]]
[[Category: Gileadi, F Von Delft O.]]
[[Category: Edwards A]]
[[Category: Shrestha, L.]]
[[Category: Gileadi O]]
[[Category: Vollmar, M.]]
[[Category: Shrestha L]]
[[Category: Yue, W W.]]
[[Category: Vollmar M]]
[[Category: Chromatin regulation]]
[[Category: Yue WW]]
[[Category: Chromatin-remodeling]]
[[Category: Von Delft F]]
[[Category: Chromodomain]]
[[Category: Histone acetylation complex]]
[[Category: Transcription]]

Latest revision as of 10:17, 1 May 2024

Crystal structure of the DNA-binding domain of human CHD1.Crystal structure of the DNA-binding domain of human CHD1.

Structural highlights

4b4c is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.62Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CHD1_HUMAN ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.[1]

See Also

References

  1. ↑ Sims RJ 3rd, Millhouse S, Chen CF, Lewis BA, Erdjument-Bromage H, Tempst P, Manley JL, Reinberg D. Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Mol Cell. 2007 Nov 30;28(4):665-76. PMID:18042460 doi:http://dx.doi.org/10.1016/j.molcel.2007.11.010

4b4c, resolution 1.62Å

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