Oligopeptide-binding protein: Difference between revisions

Latest revision as of 10:25, 16 September 2020

Function

Oligopeptide-binding protein (Opp) is a component of the

oligopeptide permease which is an ABC-type transporter system. Opp binds polypeptides up to pentapeptide in length with high affinity. Opp is required for sporulation and competence. Opp carries oligopeptides to the membrane-associated oligopeptide permease^[1].

Structural highlights

The bradykinin peptide is nestled between the 2 domains of Opp^[2]. .

. Water molecule is shown as red sphere.

Oligopeptide-binding protein (grey) complex with peptide bradykinin (cyan) and Cl- ion (green) (PDB entry 3drg)

Drag the structure with the mouse to rotate

3D structures of oligopeptide-binding protein3D structures of oligopeptide-binding protein

See ABC transporter

ReferencesReferences

↑ Monnet V. Bacterial oligopeptide-binding proteins. Cell Mol Life Sci. 2003 Oct;60(10):2100-14. PMID:14618258 doi:http://dx.doi.org/10.1007/s00018-003-3054-3
↑ Berntsson RP, Doeven MK, Fusetti F, Duurkens RH, Sengupta D, Marrink SJ, Thunnissen AM, Poolman B, Slotboom DJ. The structural basis for peptide selection by the transport receptor OppA. EMBO J. 2009 Mar 19. PMID:19300437 doi:emboj200965

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Monnet V. Bacterial oligopeptide-binding proteins. Cell Mol Life Sci. 2003 Oct;60(10):2100-14. PMID:14618258 doi:http://dx.doi.org/10.1007/s00018-003-3054-3

[2] Berntsson RP, Doeven MK, Fusetti F, Duurkens RH, Sengupta D, Marrink SJ, Thunnissen AM, Poolman B, Slotboom DJ. The structural basis for peptide selection by the transport receptor OppA. EMBO J. 2009 Mar 19. PMID:19300437 doi:emboj200965

[1]

[2]

@@ Line 1: / Line 1: @@
-{{STRUCTURE_1olc|  PDB=1olc  | SIZE=400| SCENE= |right|CAPTION=Oligopeptide-binding protein (grey) complex with tetrapeptide (green)  and UO2+2 ion [[1olc]] }}
+<StructureSection load='' size='350' side='right' caption='Oligopeptide-binding protein (grey) complex with peptide bradykinin (cyan) and Cl- ion (green) (PDB entry [[3drg]])' scene='48/488461/Cv/1'>
+== Function ==
+'''Oligopeptide-binding protein''' (Opp) is a component of the
+oligopeptide permease which is an ABC-type transporter system.  Opp binds polypeptides up to pentapeptide in length with high affinity.  Opp is required for sporulation and competence.  Opp carries oligopeptides to the membrane-associated oligopeptide permease<ref>PMID:14618258</ref>.
-<!--
+== Structural highlights ==
-Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.
+The bradykinin peptide is nestled between the 2 domains of Opp<ref>PMID:19300437</ref>. <scene name='48/488461/Cv/6'>Bradykinin peptide binding site</scene>.
-Or use the four-green-boxes-button to insert scrollable text adjacent
+*<scene name='48/488461/Cv/7'>Cl coordination site</scene>. Water molecule is shown as red sphere.
-to a Jmol applet. Check out the other buttons as well!
+</StructureSection>
--->
-'''Oligopeptide-binding protein''' (OBP) is a component of the
-oligopeptide permease which is an ABC-type transporter system.  OBP binds polypeptides up to pentapeptide in length with high affinity.  OBP is required for sporulation and competence.  OBP carries oligopeptides to the membrane-associated oligopeptide permease.
 ==3D structures of oligopeptide-binding protein==
+See [[ABC transporter]]
-[[1rkm]] – StOBP – ''Salmonella typhimurium''<br />
-[[3fto]] - LlOBP – ''Lactococcus lactis''
-'''Oligopeptide-binding protein complex with polypeptide'''
-[[1ola]], [[1olc]] – StOBP + tetrapeptide<br />
-[[2olb]], [[1jet]], [[1jeu]], [[1jev]], [[1b1h]], [[1b3f]], [[1b3g]], [[1b3l]], [[1b32]], [[1b40]], [[1b46]], [[1b4z]], [[1b5i]], [[1b5j]], [[1b51]], [[1b52]], [[1b58]], [[1b9j]], [[1b0h]], [[1b05]], [[1qka]], [[1qkb]] - StOBP + tripeptide<br />
-[[2rkm]] - StOBP + dipeptide<br />
-[[1b4h]] - StOBP + Lys-DAB-Lys<br />
-[[1b5h]] - StOBP + Lys-DPP-Lys<br />
-[[1b6h]] - StOBP + Lys-NVA-Lys<br />
-[[1b7h]] - StOBP + Lys-NLE-Lys<br />
-[[1b2h]] - StOBP + Lys-ORN-Lys<br />
-[[1b1h]] - StOBP + Lys-HPE-Lys<br />
-[[1b3h]] - StOBP + Lys-ALC-Lys<br />
-[[2z23]] - OBP + tripeptide – ''Yersinia pestis''<br />
-[[3drf]], [[3dri]] - LlOBP + octapeptide<br />
-[[3rya]], [[3ryb]] - LlOBP + nonapeptide<br />
-[[3drg]] - LlOBP + bradykinin<br />
-[[3drh]] - LlOBP + hexapeptide<br />
-[[3drj]] - LlOBP + PTH-related peptide<br />
-[[3drk]] - LlOBP + neuropeptide S
+== References ==
+<references/>
 [[Category:Topic Page]]