1dj9: Difference between revisions

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-[[Image:1dj9.png|left|200px]]
-{{STRUCTURE_1dj9|  PDB=1dj9  |  SCENE=  }}
+==CRYSTAL STRUCTURE OF 8-AMINO-7-OXONANOATE SYNTHASE (OR 7-KETO-8AMINIPELARGONATE OR KAPA SYNTHASE) COMPLEXED WITH PLP AND THE PRODUCT 8(S)-AMINO-7-OXONANONOATE (OR KAPA). THE ENZYME OF BIOTIN BIOSYNTHETIC PATHWAY.==
+<StructureSection load='1dj9' size='340' side='right'caption='[[1dj9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-===CRYSTAL STRUCTURE OF 8-AMINO-7-OXONANOATE SYNTHASE (OR 7-KETO-8AMINIPELARGONATE OR KAPA SYNTHASE) COMPLEXED WITH PLP AND THE PRODUCT 8(S)-AMINO-7-OXONANONOATE (OR KAPA). THE ENZYME OF BIOTIN BIOSYNTHETIC PATHWAY.===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1dj9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DJ9 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_10642176}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KAM:N-[7-KETO-8-AMINOPELARGONIC+ACID]-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]'>KAM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dj9 OCA], [https://pdbe.org/1dj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dj9 RCSB], [https://www.ebi.ac.uk/pdbsum/1dj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dj9 ProSAT]</span></td></tr>
-[[1dj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DJ9 OCA].
+</table>
+== Function ==
-==Reference==
+[https://www.uniprot.org/uniprot/BIOF_ECOLI BIOF_ECOLI] Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. Can also use pimeloyl-CoA instead of pimeloyl-ACP as substrate, but it is believed that pimeloyl-ACP rather than pimeloyl-CoA is the physiological substrate of BioF.<ref>PMID:20693992</ref>
-<ref group="xtra">PMID:010642176</ref><references group="xtra"/>
+== Evolutionary Conservation ==
-[[Category: 8-amino-7-oxononanoate synthase]]
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dj/1dj9_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dj9 ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Escherichia coli]]
-[[Category: Alexeev, D.]]
+[[Category: Large Structures]]
-[[Category: Alexeeva, M.]]
+[[Category: Alexeev D]]
-[[Category: Baxter, R L.]]
+[[Category: Alexeeva M]]
-[[Category: Campopiano, D J.]]
+[[Category: Baxter RL]]
-[[Category: Sawyer, L.]]
+[[Category: Campopiano DJ]]
-[[Category: Watt, R M.]]
+[[Category: Sawyer L]]
-[[Category: Webster, S P.]]
+[[Category: Watt RM]]
-[[Category: Biotin]]
+[[Category: Webster SP]]
-[[Category: Pyridoxal-5'-phosphate]]
-[[Category: Transferase]]