Sandbox reserved 392: Difference between revisions
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== Possible Acetylation of Tobramycin CoA Complex by Mycobacterium Tuberculosis == | |||
<StructureSection load='1m4d' size='500' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1dq8]])' scene=''>The study where this molecule was obtained is named "Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Tobramycin". The study suggested a reason for Tobramycin resistance. The resistance may be due to the possible acetylation of mycobacteria by Tobramycin. When Tobramycin acetylates it loses its function. The reason for the acetylation is not fully understood but a possible explanation may be that the mycobacteria needs to be acetylated so that a key biosynthetic intermediate, Mycothiol can be activated. Mycothiol is a major reducing agent in the myobacteria. <ref>Vetting, M. W., et al. "Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Tobramycin." RCSB Protien DataBase. N.p., 28 Aug.2002. Web. 13 July 2011.<http://www.rcsb.org/pdb/explore/explore.do?structureId=1M4D</ref> | |||
If this occurs it may participate in the regulation of cellular redox potential. A redox reaction or reduction-oxidation reaction is a chemical reaction that changes the oxidation state of the atom. An example of this would be the oxidation of a carbon atom to CO2. Oxidation is the loss of electrons or a gain in the oxidation state of the atom or molecule. A reduction is the gain of electrons or the decrease in oxidation state. <ref>Wikipedia. N.p., n.d. Web. 23 Sept. 2012. <Wikipedia. N.p., n.d. Web. 23 Sept. 2012. <http://en.wikipedia.org/wiki/Redox</ref> | |||
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This shows <scene name='Sandbox_reserved_392/Pap_and_his54/2'>His 54 and PAP</scene> interaction.Histidine is the smallest amino acid. I is also classified as an essential amino acid. | This shows <scene name='Sandbox_reserved_392/Pap_and_his54/2'>His 54 and PAP</scene> interaction.Histidine is the smallest amino acid. I is also classified as an essential amino acid. | ||
The other Amino acid bound to PAP is <scene name='Sandbox_reserved_392/Trp90_and_pap/2'>Typ90</scene>. Tryptophan is an essential amino acid. Tryptophan is a precursor to serotonin which is a key neurotransmitter in the gastrointestinal tract, platelets, and the central nervous system (CNS). <ref>Vetting, M. W., et al. "Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Tobramycin." RCSB Protien DataBase. N.p., 28 Aug.2002. Web. 13 July 2011.<http://www.rcsb.org/pdb/explore/explore.do?structureId=1M4D</ref> | The other Amino acid bound to PAP is <scene name='Sandbox_reserved_392/Trp90_and_pap/2'>Typ90</scene>. Tryptophan is an essential amino acid. Tryptophan is a precursor to serotonin which is a key neurotransmitter in the gastrointestinal tract, platelets, and the central nervous system (CNS). <ref>Vetting, M. W., et al. "Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Tobramycin." RCSB Protien DataBase. N.p., 28 Aug.2002. Web. 13 July 2011.<http://www.rcsb.org/pdb/explore/explore.do?structureId=1M4D</ref> | ||
= References = | = References = | ||
{{Reflist}} | {{Reflist}} | ||
</StructureSection> | </StructureSection> | ||