1b9w: Difference between revisions

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-[[Image:1b9w.png|left|200px]]
-{{STRUCTURE_1b9w|  PDB=1b9w  |  SCENE=  }}
+==C-TERMINAL MEROZOITE SURFACE PROTEIN 1 FROM PLASMODIUM CYNOMOLGI==
+<StructureSection load='1b9w' size='340' side='right'caption='[[1b9w]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1b9w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_cynomolgi Plasmodium cynomolgi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B9W FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b9w OCA], [https://pdbe.org/1b9w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b9w RCSB], [https://www.ebi.ac.uk/pdbsum/1b9w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b9w ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q25659_9APIC Q25659_9APIC]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b9/1b9w_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b9w ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The C-terminal proteolytic processing product of merozoite surface protein 1 (MSP1) appears essential for successful erythrocyte invasion by the malarial parasite, Plasmodium. We have determined the crystal structure at 1.8 A resolution of a soluble baculovirus-recombinant form of the protein from P. cynomolgi, which confers excellent protective efficacy in primate vaccination trials. The structure comprises two EGF-like domains, and sequence comparisons strongly suggest that the same conformation is present in all species of Plasmodium, including P. falciparum and P. vivax, which are pathogenic in man. In particular, conserved interdomain contacts between the two EGF modules should preserve the compact form of the molecule in all species. Implications of the crystal structure for anti-malarial vaccine development are discussed.
-===C-TERMINAL MEROZOITE SURFACE PROTEIN 1 FROM PLASMODIUM CYNOMOLGI===
+The crystal structure of C-terminal merozoite surface protein 1 at 1.8 A resolution, a highly protective malaria vaccine candidate.,Chitarra V, Holm I, Bentley GA, Petres S, Longacre S Mol Cell. 1999 Apr;3(4):457-64. PMID:10230398<ref>PMID:10230398</ref>
-{{ABSTRACT_PUBMED_10230398}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 1b9w" style="background-color:#fffaf0;"></div>
-[[1b9w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_cynomolgi Plasmodium cynomolgi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9W OCA].
+== References ==
+<references/>
-==Reference==
+__TOC__
-<ref group="xtra">PMID:010230398</ref><references group="xtra"/>
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Plasmodium cynomolgi]]
-[[Category: Bentley, G A.]]
+[[Category: Bentley GA]]
-[[Category: Chitarra, V.]]
+[[Category: Chitarra V]]
-[[Category: Holm, I.]]
+[[Category: Holm I]]
-[[Category: Longacre, S.]]
+[[Category: Longacre S]]
-[[Category: Candidate malaria vaccine]]
-[[Category: Msp-1]]
-[[Category: Surface antigen]]
-[[Category: Surface protein]]