1au7: Difference between revisions
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==PIT-1 MUTANT/DNA COMPLEX== | |||
<StructureSection load='1au7' size='340' side='right'caption='[[1au7]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1au7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AU7 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1au7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1au7 OCA], [https://pdbe.org/1au7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1au7 RCSB], [https://www.ebi.ac.uk/pdbsum/1au7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1au7 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PIT1_RAT PIT1_RAT] Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/au/1au7_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1au7 ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[Art:Molecular Sculpture|Art:Molecular Sculpture]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[ | |||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Aggarwal | [[Category: Aggarwal AK]] | ||
[[Category: Jacobson | [[Category: Jacobson EM]] | ||
[[Category: Leon-Del-Rio | [[Category: Leon-Del-Rio A]] | ||
[[Category: Li | [[Category: Li P]] | ||
[[Category: Rosenfeld | [[Category: Rosenfeld MG]] | ||
Latest revision as of 09:33, 7 February 2024
PIT-1 MUTANT/DNA COMPLEXPIT-1 MUTANT/DNA COMPLEX
Structural highlights
FunctionPIT1_RAT Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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