17gs: Difference between revisions

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-[[Image:17gs.png|left|200px]]
-{{STRUCTURE_17gs|  PDB=17gs  |  SCENE=  }}
+==GLUTATHIONE S-TRANSFERASE P1-1==
+<StructureSection load='17gs' size='340' side='right'caption='[[17gs]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[17gs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=17GS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=17GS FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTX:S-HEXYLGLUTATHIONE'>GTX</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=17gs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=17gs OCA], [https://pdbe.org/17gs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=17gs RCSB], [https://www.ebi.ac.uk/pdbsum/17gs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=17gs ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/7g/17gs_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=17gs ConSurf].
+<div style="clear:both"></div>
-===GLUTATHIONE S-TRANSFERASE P1-1===
+==See Also==
+*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
-{{ABSTRACT_PUBMED_9398518}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[17gs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=17GS OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:009398518</ref><references group="xtra"/>
-[[Category: Glutathione transferase]]
 [[Category: Homo sapiens]]
-[[Category: Bello, M Lo.]]
+[[Category: Large Structures]]
-[[Category: Oakley, A J.]]
+[[Category: Lo Bello M]]
-[[Category: Parker, M W.]]
+[[Category: Oakley AJ]]
-[[Category: Detoxification]]
+[[Category: Parker MW]]
-[[Category: Glutathione transferase]]
-[[Category: K54a mutant]]
-[[Category: Transferase]]