2idv: Difference between revisions
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==Crystal structure of wheat C113S mutant EIF4E bound TO 7-methyl-GDP== | |||
<StructureSection load='2idv' size='340' side='right'caption='[[2idv]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2idv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Triticum_aestivum Triticum aestivum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IDV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IDV FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2idv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2idv OCA], [https://pdbe.org/2idv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2idv RCSB], [https://www.ebi.ac.uk/pdbsum/2idv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2idv ProSAT]</span></td></tr> | ||
[[2idv]] is a 1 chain structure with sequence from [ | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/IF4E1_WHEAT IF4E1_WHEAT] Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/id/2idv_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2idv ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Eukaryotic initiation factor|Eukaryotic initiation factor]] | *[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]] | ||
__TOC__ | |||
</StructureSection> | |||
< | [[Category: Large Structures]] | ||
[[Category: Triticum aestivum]] | [[Category: Triticum aestivum]] | ||
[[Category: Browning | [[Category: Browning KS]] | ||
[[Category: Dhaliwal | [[Category: Dhaliwal S]] | ||
[[Category: Dutt-Chaudhuri | [[Category: Dutt-Chaudhuri A]] | ||
[[Category: Hoffman | [[Category: Hoffman DW]] | ||
[[Category: Monzingo | [[Category: Monzingo AF]] | ||
[[Category: Robertus | [[Category: Robertus JD]] | ||
[[Category: Sadow | [[Category: Sadow J]] | ||
Latest revision as of 15:14, 6 March 2024
Crystal structure of wheat C113S mutant EIF4E bound TO 7-methyl-GDPCrystal structure of wheat C113S mutant EIF4E bound TO 7-methyl-GDP
Structural highlights
FunctionIF4E1_WHEAT Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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