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[[Image:1jfc.png|left|200px]]


{{STRUCTURE_1jfc|  PDB=1jfc  |  SCENE=  }}
==X-ray structure of nitric oxide reductase (cytochrome P450nor) in the ferrous CO state at atomic resolution==
 
<StructureSection load='1jfc' size='340' side='right'caption='[[1jfc]], [[Resolution|resolution]] 1.05&Aring;' scene=''>
===X-ray structure of nitric oxide reductase (cytochrome P450nor) in the ferrous CO state at atomic resolution===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1jfc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusarium_oxysporum Fusarium oxysporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JFC FirstGlance]. <br>
{{ABSTRACT_PUBMED_11752781}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.05&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jfc OCA], [https://pdbe.org/1jfc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jfc RCSB], [https://www.ebi.ac.uk/pdbsum/1jfc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jfc ProSAT], [https://www.topsan.org/Proteins/RSGI/1jfc TOPSAN]</span></td></tr>
[[1jfc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fusarium_oxysporum Fusarium oxysporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFC OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/NOR_FUSOX NOR_FUSOX] Nitric oxide reductase which is involved in a dissimilatory reduction of nitrite. Acts as a nitric oxide reductase. Is able to reduce nitrate and nitrite to a gaseous form of N(2)O when oxygen supply is limited or discontinued. May function as a detoxification mechanism.<ref>PMID:2040619</ref> <ref>PMID:12105197</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jf/1jfc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jfc ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Cytochrome P450|Cytochrome P450]]
*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:011752781</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Fusarium oxysporum]]
[[Category: Fusarium oxysporum]]
[[Category: Nitric-oxide reductase]]
[[Category: Large Structures]]
[[Category: Adachi, S.]]
[[Category: Adachi S]]
[[Category: Park, S Y.]]
[[Category: Park SY]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Shimizu H]]
[[Category: Shimizu, H.]]
[[Category: Shiro Y]]
[[Category: Shiro, Y.]]
[[Category: Atomic resolution]]
[[Category: Carbon monoxide]]
[[Category: Cytochrome p450nor]]
[[Category: Nitric oxide reductase]]
[[Category: Oxidoreductase]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Structural genomic]]

Latest revision as of 16:24, 13 March 2024

X-ray structure of nitric oxide reductase (cytochrome P450nor) in the ferrous CO state at atomic resolutionX-ray structure of nitric oxide reductase (cytochrome P450nor) in the ferrous CO state at atomic resolution

Structural highlights

1jfc is a 1 chain structure with sequence from Fusarium oxysporum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.05Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

NOR_FUSOX Nitric oxide reductase which is involved in a dissimilatory reduction of nitrite. Acts as a nitric oxide reductase. Is able to reduce nitrate and nitrite to a gaseous form of N(2)O when oxygen supply is limited or discontinued. May function as a detoxification mechanism.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Shoun H, Tanimoto T. Denitrification by the fungus Fusarium oxysporum and involvement of cytochrome P-450 in the respiratory nitrite reduction. J Biol Chem. 1991 Jun 15;266(17):11078-82. PMID:2040619
  2. ↑ Zhang L, Kudo T, Takaya N, Shoun H. The B' helix determines cytochrome P450nor specificity for the electron donors NADH and NADPH. J Biol Chem. 2002 Sep 13;277(37):33842-7. Epub 2002 Jul 8. PMID:12105197 doi:http://dx.doi.org/10.1074/jbc.M203923200

1jfc, resolution 1.05Å

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