3sbt: Difference between revisions

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[[Image:3sbt.png|left|200px]]


{{STRUCTURE_3sbt|  PDB=3sbt  |  SCENE=  }}
==Crystal structure of a Aar2-Prp8 complex==
 
<StructureSection load='3sbt' size='340' side='right'caption='[[3sbt]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
===Crystal structure of a Aar2-Prp8 complex===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3sbt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SBT FirstGlance]. <br>
{{ABSTRACT_PUBMED_21764848}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.799&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sbt OCA], [https://pdbe.org/3sbt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sbt RCSB], [https://www.ebi.ac.uk/pdbsum/3sbt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sbt ProSAT]</span></td></tr>
[[3sbt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SBT OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/PRP8_YEAST PRP8_YEAST] Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region. Also has a role in cell cycle.<ref>PMID:2835658</ref> <ref>PMID:9150140</ref> <ref>PMID:12773561</ref> <ref>PMID:18779563</ref>


==See Also==
==See Also==
*[[Pre-mRNA-splicing factor|Pre-mRNA-splicing factor]]
*[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:021764848</ref><references group="xtra"/>
__TOC__
[[Category: Saccharomyces cerevisiae]]
</StructureSection>
[[Category: Holton, N.]]
[[Category: Large Structures]]
[[Category: Santos, K F.]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Wahl, M C.]]
[[Category: Holton N]]
[[Category: Weber, G.]]
[[Category: Santos KF]]
[[Category: Rnaseh like domain]]
[[Category: Wahl MC]]
[[Category: Splicing]]
[[Category: Weber G]]
[[Category: U5 snrnp assembly]]
[[Category: Vhs like domain]]

Latest revision as of 12:49, 1 March 2024

Crystal structure of a Aar2-Prp8 complexCrystal structure of a Aar2-Prp8 complex

Structural highlights

3sbt is a 2 chain structure with sequence from Saccharomyces cerevisiae S288C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.799Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PRP8_YEAST Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region. Also has a role in cell cycle.[1] [2] [3] [4]

See Also

References

  1. ↑ Jackson SP, Lossky M, Beggs JD. Cloning of the RNA8 gene of Saccharomyces cerevisiae, detection of the RNA8 protein, and demonstration that it is essential for nuclear pre-mRNA splicing. Mol Cell Biol. 1988 Mar;8(3):1067-75. PMID:2835658
  2. ↑ Abovich N, Rosbash M. Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals. Cell. 1997 May 2;89(3):403-12. PMID:9150140
  3. ↑ McPheeters DS, Muhlenkamp P. Spatial organization of protein-RNA interactions in the branch site-3' splice site region during pre-mRNA splicing in yeast. Mol Cell Biol. 2003 Jun;23(12):4174-86. PMID:12773561
  4. ↑ Yang K, Zhang L, Xu T, Heroux A, Zhao R. Crystal structure of the beta-finger domain of Prp8 reveals analogy to ribosomal proteins. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13817-22. Epub 2008 Sep 8. PMID:18779563

3sbt, resolution 1.80Å

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